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Published on: October 9, 2017
Neuroprotective gain of Apelin/APJ system
Jia-Xiu Zhou1, Nian-Nian Shuai2, Bo Wang2
1Department of Anesthesiology, Affiliated Longhua People's Hospital, Southern Medical University, Shenzhen, Guangdong 518109, PR China; Guangxi Key Laboratory of Brain and Cognitive Neuroscience, Faculty of Basic Medical Sciences, Faculty of Basic Medical Sciences, Guilin Medical University, Guilin, Guangxi 541199, PR China.
Abstract:
Apelin is an endogenous ligand of G protein-coupled receptor APJ. In recent years, many studies have shown that the apelin/APJ system has neuroprotective properties, such as anti-inflammatory, anti-oxidative stress, anti-apoptosis, and regulating autophagy, blocking excitatory toxicity. Apelin/APJ system has been proven to play a role in various neurological diseases and may be a promising therapeutic target for nervous system diseases. In this paper, the neuroprotective properties of the apelin/APJ system and its role in neurologic disorders are reviewed. Further understanding of the pathophysiological effect and mechanism of the apelin/APJ system in the nervous system will help develop new therapeutic interventions for various neurological diseases.
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