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Related Experiment Video

Updated: Nov 16, 2025

Evaluation of a Reliable Biomarker in a Cecal Ligation and Puncture-Induced Mouse Model of Sepsis

Evaluation of a Reliable Biomarker in a Cecal Ligation and Puncture-Induced Mouse Model of Sepsis

Published on: December 9, 2022

Emerging therapeutic targets for sepsis.

Elizabeth W Tindal¹, Brandon E Armstead¹, Sean F Monaghan¹

¹Division of Surgical Research, Department of Surgery, Brown University, Rhode Island Hospital, Providence, RI, USA.

Expert Opinion on Therapeutic Targets

|March 1, 2021

Summary

Sepsis research focuses on understanding the immune response to infection. New therapeutic strategies are needed to combat sepsis-associated mortality, requiring a combination of approaches.

Keywords:

Checkpoint proteins epigenetics immunosuppression inflammation microbiome sepsis

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Area of Science:

Critical care medicine
Immunology
Infectious diseases

Background:

Sepsis involves a dysregulated host response to infection, leading to significant morbidity and mortality.
Current research aims to develop reliable, broadly effective, and etiologically based therapeutic interventions for sepsis.

Purpose of the Study:

To evaluate experimental mammalian models and clinical trials in sepsis research.
To assess evolving therapeutics for sepsis, building upon past and current treatments.

Main Methods:

Literature review of relevant studies published between 1987 and 2020.
Analysis of key experimental models and clinical trial data in sepsis.

Main Results:

The complexity of sepsis and immune responses has hindered the development of a single, universally effective cure.
Innovative approaches are exploring modifications to disease processes and underlying patient factors.

Conclusions:

Improving outcomes for sepsis requires a multifaceted therapeutic strategy.
Future research should focus on combination therapies and addressing individual patient factors to reduce sepsis-associated morbidity and mortality.