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The Microenvironment in Myeloproliferative Neoplasms

Gajalakshmi Ramanathan1, Angela G Fleischman2

  • 1Division of Hematology/Oncology, Department of Medicine, University of California, 839 Health Sciences Road, Sprague Hall B100, Irvine, CA 92617, USA.

Hematology/Oncology Clinics of North America
|March 1, 2021
PubMed

Insights

Chronic inflammation drives myeloproliferative neoplasms (MPNs) and their symptoms. Understanding the inflammatory environment and targeting its cellular players offers new therapeutic strategies for MPN patients.

Area of Science:

  • Hematology
  • Oncology
  • Immunology

Background:

  • Chronic inflammation is a key characteristic of myeloproliferative neoplasms (MPNs).
  • Elevated proinflammatory cytokines are present in all MPN subtypes.
  • Systemic inflammation contributes to MPN symptoms, thrombosis, atherosclerosis, and disease progression.

Purpose of the Study:

  • To describe the inflammatory milieu in MPN.
  • To explore the role of soluble factors and cellular mediators in MPN inflammation.
  • To discuss the prognostic value of cytokine measurements and potential targeted therapies.

Main Methods:

  • Review of the inflammatory milieu in MPN.
  • Analysis of soluble factors and cellular mediators.
  • Discussion of prognostic value and therapeutic strategies.

Main Results:

  • Neoplastic cells and their progeny drive inflammation in MPN.
  • Nonmalignant cells also contribute to cytokine secretion.
  • Cytokine levels and cellular mediators define the inflammatory landscape in MPN.

Conclusions:

  • The inflammatory milieu is crucial in MPN pathogenesis and progression.
  • Cytokine measurements hold prognostic value for MPN patients.
  • Targeting cellular inflammation mediators presents a promising therapeutic avenue for MPNs.
Keywords:
CytokinesInflammationMicroenvironmentMyeloid cellsMyeloproliferative neoplasmPrognosis

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