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Robust Ligature-Induced Model of Murine Periodontitis for the Evaluation of Oral Neutrophils
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Gingival squamous cell carcinoma masquerading as necrotizing ulcerative periodontitis
Saif Khan1, Kafil Akhtar2, Abdul Ahad3
1Department of Periodontics, Dr. Ziauddin Ahmad Dental College, Aligarh, Uttar Pradesh, India.
Journal of Indian Society of Periodontology
|March 1, 2021
Summary
Necrotizing ulcerative periodontitis (NUP) can rarely mimic squamous cell carcinoma (SCC). This case highlights the importance of histological examination for accurate diagnosis and timely cancer management.
Area of Science:
- Oral pathology
- Oncology
- Periodontology
Background:
- Necrotizing ulcerative periodontitis (NUP) is a severe periodontal disease often linked to compromised immunity.
- Gingival squamous cell carcinoma (SCC) can present atypically, potentially delaying diagnosis.
Observation:
- A 34-year-old male presented with clinical signs suggestive of NUP affecting mandibular posterior teeth.
- Initial clinical presentation mimicked necrotizing ulcerative periodontitis, masking a malignant underlying condition.
Findings:
- Histopathological examination confirmed well-differentiated squamous cell carcinoma (SCC) despite the NUP-like clinical appearance.
- Immunohistochemistry revealed epithelial-mesenchymal transition markers (decreased E-cadherin, increased vimentin), indicating invasive and metastatic potential.
Implications:
- Misdiagnosis of NUP can lead to delayed detection of gingival SCC, negatively impacting prognosis.
- This case underscores the necessity of thorough histopathological evaluation for seemingly benign necrotizing oral lesions.
- Early referral to oncology is crucial for managing potentially metastatic SCC presenting as NUP.
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