Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Gonadal dysgenesis: on mature reflection!

G A Lees1, O J Corrado, W E Bagnall

  • 1Department of Medicine (Elderly), St James's University Hospital, Leeds.

Age and Ageing
|January 1, 1988
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Patient-led training on patient safety: a pilot study to test the feasibility and acceptability of an educational intervention.

Medical teacher·2013
Same author

What do specialist registrars know about clinical governance?

Hospital medicine (London, England : 1998)·2005
Same author

Hospital-at-home.

Age and ageing·2001
Same author

Caring for older hospital-at-home patients.

Age and ageing·2000
Same author

Prospective study of the risk of Clostridium difficile diarrhoea in elderly patients following treatment with cefotaxime or piperacillin-tazobactam.

Alimentary pharmacology & therapeutics·1999
Same author

Measures are needed to allow elderly inpatients to vote in general elections.

BMJ (Clinical research ed.)·1998

This case report details the oldest diagnosed patient with 46XY pure gonadal dysgenesis at 93 years old. This rare disorder of sexual differentiation is typically identified much earlier in life.

Area of Science:

  • Endocrinology
  • Genetics
  • Reproductive Medicine

Background:

  • Disorders of sexual differentiation (DSD) are typically diagnosed in infancy or childhood.
  • Late-onset diagnosis of DSD is uncommon, particularly in advanced age.

Observation:

  • A 93-year-old patient presented with a late diagnosis of 46XY pure gonadal dysgenesis.
  • This represents the oldest reported case of this specific DSD.

Findings:

  • The patient's karyotype was 46XY, indicating male chromosomal sex.
  • Pure gonadal dysgenesis involves underdeveloped gonads in individuals with a 46XY karyotype.

Implications:

  • This case expands the known age range for DSD diagnosis.
  • Highlights the importance of considering DSD in elderly patients with relevant clinical presentations.

Related Experiment Videos

  • Contributes to understanding the long-term clinical spectrum of 46XY pure gonadal dysgenesis.