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Related Experiment Video

Updated: Nov 16, 2025

Determination of Reproductive Competence by Confirming Pubertal Onset and Performing a Fertility Assay in Mice and Rats

Determination of Reproductive Competence by Confirming Pubertal Onset and Performing a Fertility Assay in Mice and Rats

Published on: October 13, 2018

Timing the Juvenile-Adult Neurohormonal Transition: Functions and Evolution.

Celia G Barredo¹, Beatriz Gil-Marti¹, Derya Deveci²

¹Molecular Physiology of Behavior Laboratory, Department of Molecular, Cellular and Developmental Neurobiology, Cajal Institute, Spanish National Research Council (CSIC), Madrid, Spain.

Frontiers in Endocrinology

|March 1, 2021

Summary

This summary is machine-generated.

Reproductive maturation in mammals and insects may share a common evolutionary origin. Key neuroendocrine circuits regulating developmental transitions like puberty and metamorphosis could be ancient, challenging previous convergent evolution theories.

Keywords:

Drosophila Urbilateria juvenile-adult transition metamorphosis neuro-hormonal regulation neuroendocrine axis puberty sleep

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Area of Science:

Developmental Biology
Evolutionary Biology
Neuroendocrinology

Background:

Puberty and metamorphosis are critical developmental transitions.
Neuroendocrine circuitry in the brain times these transitions in vertebrates.
These pathways also influence metabolism, sleep, and behavior.

Purpose of the Study:

To investigate the evolutionary origins of neuroendocrine axes regulating juvenile-to-adult transitions.
To challenge the notion that these pathways evolved convergently in mammals and insects.
To explore the potential presence of these circuits in the common bilaterian ancestor, Urbilateria.

Main Methods:

Comparative analysis of neuroendocrine signaling pathways across different species.
Examination of genetic networks involved in developmental transitions.
Phylogenetic reconstruction to infer evolutionary relationships of neuroendocrine circuits.

Main Results:

Recent findings suggest that neuroendocrine circuits regulating developmental transitions may not be analogous but homologous.
Evidence points to the presence of these circuits in the ancient bilaterian ancestor (Urbilateria).
Initial signaling pathways appear to have a single evolutionary origin, with conserved functions.

Conclusions:

The regulation of puberty and metamorphosis might stem from a shared evolutionary history, not just convergent evolution.
Conserved molecular players and co-opted genetic networks highlight the deep evolutionary roots of developmental timing.
Understanding these ancient circuits provides insights into conserved biological processes across diverse species.