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Updated: Nov 16, 2025
04:23
A Murine Model of Dengue Virus-induced Acute Viral Encephalitis-like Disease
Published on: April 28, 2019
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COVID-19 Encephalopathy in Adults
Paavani Atluri1, Deepa Vasireddy2, Srikrishna Malayala3
1Internal Medicine, Bay Area Hospital, Coos bay, USA.
Cureus
|March 1, 2021
Summary
The SARS-CoV-2 virus can cause acute encephalopathy, a severe brain condition. Prompt treatment with remdesivir and steroids helped two patients recover their cognitive function.
Area of Science:
- Neurology
- Infectious Diseases
- Virology
Background:
- COVID-19 commonly presents with influenza-like symptoms.
- Neurological manifestations occur in a significant percentage of hospitalized COVID-19 patients.
- The pathophysiology of COVID-19-related neurological complications is not fully understood.
Observation:
- Two patients presented with acute encephalopathy as their primary COVID-19 symptom.
- Both patients had positive SARS-CoV-2 tests and no other identified causes for their condition.
- One patient had pre-existing mild cognitive impairment, and the other had dementia.
Findings:
- Both patients regained consciousness within 24-48 hours of treatment initiation.
- Patients responded well to standard remdesivir and steroid therapy.
- Neurological symptoms resolved, and patients returned to their baseline cognitive function.
Implications:
- SARS-CoV-2 is a potential causative agent of acute encephalopathy.
- This suggests a direct or indirect viral impact on the central nervous system.
- Further research is needed to elucidate the mechanisms behind COVID-19-induced neurological dysfunction.
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