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Phosphorylation regulates cullin-based ubiquitination in tumorigenesis

Yifan Chen1, Xuejing Shao1, Ji Cao1

  • 1Zhejiang Province Key Laboratory of Anti-Cancer Drug Research, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310058, China.

Acta Pharmaceutica Sinica. B
|March 1, 2021
PubMed
Summary

Phosphorylation and ubiquitination crosstalk regulates cell processes and disease, particularly cancer. Understanding these mechanisms offers new therapeutic strategies for tumor intervention by targeting key proteins.

Keywords:
AIRE, autoimmune regulatorAKT, AKT serine/threonine kinaseATR, ataxia telangiectasia-mutated and Rad3-relatedBCL2, BCL2 apoptosis regulatorBMAL1, aryl hydrocarbon receptor nuclear translocator likeCDK2/4, cyclin dependent kinase 2/4CDT2, denticleless E3 ubiquitin protein ligase homologCHK1, checkpoint kinase 1CK1/2, casein kinase I/IICLOCK, clock circadian regulatorCOMMD1, copper metabolism domain containing 1CRL, cullin-RING ligaseCRY1, cryptochrome circadian regulator 1CSN, COP9 signalosomeCi, cubitus interruptusCrosstalkCullin-RING ligasesDDB1, damage specific DNA binding protein 1DYRK1A/B, dual-specificity tyrosine-phosphorylation-regulated kinases 1A/BDegradationEMT, epithelial–mesenchymal transitionERG, ETS transcription factor ERGERK, mitogen-activated protein kinase 1EXO1, exonuclease 1FBW7, F-box and WD repeat domain containing 7FBXL3, F-box and leucine rich repeat proteinFBXO3/31, F-box protein 3/31FZR1, fizzy and cell division cycle 20 related 1HCC, hepatocellular carcinomasHIB, Hedghog-induced MATH and BTB domain-containing proteinHIF1α, NF-κB and hypoxia inducible factor 1 subunit alphaID2, inhibitor of DNA binding 2JAB1, c-Jun activation domain binding protein-1KBTBD8, kelch repeat and BTB domain containing 8KDM2B, lysine demethylase 2BKEAP1, kelch like ECH associated protein 1KLHL3, kelch like family member 3KRAS, KRAS proto-oncogene, GTPaseKinasesMYC, MYC proto-oncogene, bHLH transcription factorNEDD8, NEDD8 ubiquitin like modifierNOLC1, nucleolar and coiled-body phosphoprotein 1NRF2, nuclear factor, erythroid 2 like 2P-TEFb, positive transcription elongation factor bPDL1, programmed death ligand 1PKC, protein kinase CPKM2, pyruvate kinase M2 isoformPYGO2, pygopus 2PhosphorylationRA, retinoic acidRARα, RA receptor αRRM2, ribonucleotide reductase regulatory subunit M2SNAIL1, snail family transcriptional repressor 1SOCS6, suppressor of cytokine signaling 6SPOP, speckle-type POZ proteinSRC-3, nuclear receptor coactivator 3TCN, triciribine hydrateTCOF1, treacle ribosome biogenesis factor 1TRF1, telomeric repeat binding factor 1Targeted therapyTumorigenesisUSP37, ubiquitin specific peptidase 37UbiquitinationVHL, von Hippel-Lindau tumor suppressorVps34, phosphatidylinositol 3-kinase catalytic subunit type 3XBP1, X-box binding protein 1ZBTB16, zinc finger and BTB domain containing 16c-Fos, Fos proto-oncogene, AP-1 transcription factor subunitp130Cas, BCAR1 scaffold protein, Cas family member

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