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In Silico Identification and Characterization of circRNAs During Host-Pathogen Interactions
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In Silico Identification and Characterization of circRNAs During Host-Pathogen Interactions

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Regulatory Effects of Circular RNAs on Host Genes in Human Cancer

Xiong Wang1, Huijun Li1, Yanjun Lu1

  • 1Department of Laboratory Medicine, Tongji Hospital, Tongji Medical College of Huazhong University of Science and Technology, Wuhan, China.

Frontiers in Oncology
|March 1, 2021
PubMed

Insights

Circular RNAs (circRNAs) are key regulators in human cancers, influencing processes like proliferation and metastasis. This review highlights how circRNAs modulate their host genes, impacting cancer progression and offering new therapeutic targets.

Area of Science:

  • Molecular Biology
  • Genetics
  • Oncology

Background:

  • Circular RNAs (circRNAs) are covalently closed RNA molecules with stable, tissue-specific expression.
  • They play critical roles in cancer, acting as tumor suppressors or oncogenes.
  • circRNAs function as miRNA/protein sponges, protein scaffolds, or translation templates.

Purpose of the Study:

  • To review the latest research on how circRNAs regulate their host genes in human cancers.
  • To elucidate the mechanisms by which circRNAs influence cancer progression via host gene modulation.
  • To enhance understanding of the circRNA-host gene interaction in the context of cancer.

Main Methods:

  • Literature review of recent studies on circRNA-host gene interactions in cancer.
  • Analysis of molecular mechanisms underlying circRNA-mediated gene regulation.
  • Synthesis of findings on the roles of circRNAs in cancer hallmarks.

Main Results:

  • circRNAs significantly impact cancer progression by modulating host gene expression and function.
  • These regulatory interactions are implicated in tumorigenesis, proliferation, apoptosis, metastasis, invasion, and chemoresistance.
  • circRNAs offer insights into novel diagnostic and therapeutic strategies for cancer.

Conclusions:

  • circRNAs are crucial regulators of host genes in human cancers.
  • Understanding circRNA-host gene interactions is vital for comprehending cancer biology.
  • Further research into these interactions may lead to targeted cancer therapies.
Keywords:
cancercircRNAhost genemiRNA spongetranscription

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