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Published on: January 27, 2023
Management of Patent Ductus Arteriosus in Premature Infants in 2020
Sarah Parkerson1, Ranjit Philip2, Ajay Talati3
1Department of Pediatrics, University of Tennessee, Memphis, TN, United States.
Insights
The patent ductus arteriosus (PDA) in neonates remains a debated cardiac condition. Transcatheter PDA closure (TCPC) is introduced as a potential new treatment option for premature infants.
Area of Science:
- Neonatal cardiology
- Pediatric cardiac surgery
- Perinatal medicine
Background:
- Patent ductus arteriosus (PDA) is a common neonatal cardiac condition.
- Treatment decisions for PDA are debated due to limited long-term benefits of interventions.
- Practice variations persist among specialists and institutions.
Purpose of the Study:
- To review the history, embryology, histology, and hemodynamic significance of PDA.
- To examine the existing literature on PDA closure in premature infants.
- To introduce transcatheter PDA closure (TCPC) as a potential therapeutic option.
Main Methods:
- Literature review of PDA history, embryology, and hemodynamics.
- Analysis of studies on PDA closure in premature infants.
- Discussion of transcatheter PDA closure (TCPC) techniques and outcomes.
Main Results:
- PDA remains a significant clinical challenge in neonates.
- Evidence for long-term benefits of current PDA interventions is limited.
- Transcatheter PDA closure (TCPC) shows promise as a minimally invasive option.
Conclusions:
- The management of PDA in neonates requires careful consideration.
- Transcatheter PDA closure (TCPC) offers a potential advancement in treating PDA in premature infants.
- Further research is needed to establish TCPC as a standard treatment.
Abstract:
The patent ductus arteriosus (PDA) is the most commonly found cardiac condition in neonates. While there have been several studies and thousands of publications on the topic, the decision to treat the PDA is still strongly debated among cardiologists, surgeons, and neonatologists. This is in part due to the shortage of long-term benefits with the interventions studied. Practice variations still exist within sub-specialties and centers. This article briefly summarizes the history, embryology and histology of the PDA. It also succinctly discusses the hemodynamic significance of a PDA which builds the framework to review all the available literature on PDA closure in premature infants, though not a paradigm shift just yet; it introduces transcatheter PDA closure (TCPC) as a possible armament to the clinician for this age-old problem.
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