Management of Patent Ductus Arteriosus in Premature Infants in 2020

Sarah Parkerson1, Ranjit Philip2, Ajay Talati3

  • 1Department of Pediatrics, University of Tennessee, Memphis, TN, United States.

Insights

The patent ductus arteriosus (PDA) in neonates remains a debated cardiac condition. Transcatheter PDA closure (TCPC) is introduced as a potential new treatment option for premature infants.

Area of Science:

  • Neonatal cardiology
  • Pediatric cardiac surgery
  • Perinatal medicine

Background:

  • Patent ductus arteriosus (PDA) is a common neonatal cardiac condition.
  • Treatment decisions for PDA are debated due to limited long-term benefits of interventions.
  • Practice variations persist among specialists and institutions.

Purpose of the Study:

  • To review the history, embryology, histology, and hemodynamic significance of PDA.
  • To examine the existing literature on PDA closure in premature infants.
  • To introduce transcatheter PDA closure (TCPC) as a potential therapeutic option.

Main Methods:

  • Literature review of PDA history, embryology, and hemodynamics.
  • Analysis of studies on PDA closure in premature infants.
  • Discussion of transcatheter PDA closure (TCPC) techniques and outcomes.

Main Results:

  • PDA remains a significant clinical challenge in neonates.
  • Evidence for long-term benefits of current PDA interventions is limited.
  • Transcatheter PDA closure (TCPC) shows promise as a minimally invasive option.

Conclusions:

  • The management of PDA in neonates requires careful consideration.
  • Transcatheter PDA closure (TCPC) offers a potential advancement in treating PDA in premature infants.
  • Further research is needed to establish TCPC as a standard treatment.

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