Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Elevated plasma copper in chronic renal failure.

J H Sondheimer1, S K Mahajan, D L Rye

  • 1Department of Medicine, Wayne State University School of Medicine, Detroit, MI 48201.

The American Journal of Clinical Nutrition
|May 1, 1988
PubMed
Summary

Plasma copper levels are elevated in patients with chronic kidney disease, whether on dialysis or not. This increase in copper is not due to higher ceruloplasmin levels, indicating a different underlying mechanism in uremia.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Clinical, hematological and biochemical findings in bovines with primary abomasal impaction.

Schweizer Archiv fur Tierheilkunde·2026
Same author

Genomic insights into six dog breeds owned in India: a ddRAD sequencing approach.

BMC genomics·2026
Same author

Chasing clarity in acute pancreatitis: Comparing computed tomography severity index and APACHE-II score in predicting severity in Indian patients.

Medical journal, Armed Forces India·2026
Same author

Hereditary ovarian tumour syndromes: current update on genetics and imaging.

Clinical radiology·2020
Same author

A Comparative Evaluation of Intracanal Calcium Hydroxide Removal with Hand File, Rotary File, and Passive Ultrasonic Irrigation: An <i>In Vitro</i> Study.

Journal of pharmacy & bioallied sciences·2019
Same author

Musculoskeletal Disorders and Mental Health-related Issues as Occupational Hazards among Dental Practitioners in Salem City: A Cross-sectional Study.

Journal of pharmacy & bioallied sciences·2017

Area of Science:

  • Nephrology
  • Biochemistry
  • Trace Element Metabolism

Background:

  • Hypercupremia, or elevated plasma copper, is observed in patients undergoing chronic dialysis.
  • Understanding the specific mechanisms behind copper dysregulation in uremia is crucial for patient management.

Purpose of the Study:

  • To investigate plasma copper (PCu) and ceruloplasmin (Cp) levels in patients with varying stages of chronic kidney disease.
  • To differentiate between dialysis-associated and non-dialysis-associated hypercupremia in uremic patients.

Main Methods:

  • Studied plasma copper and ceruloplasmin in hemodialysis patients, peritoneal dialysis patients, pre-dialysis uremic patients, and healthy controls.
  • Measured non-ceruloplasmin copper and chelatable copper to assess copper distribution and availability.

Related Experiment Videos

Main Results:

  • All patient groups (hemodialysis, peritoneal dialysis, pre-dialysis uremia) exhibited significantly elevated plasma copper compared to controls.
  • Plasma ceruloplasmin levels did not differ significantly across the study groups.
  • Calculated non-ceruloplasmin copper and measured chelatable copper were significantly higher in all uremic patient groups compared to controls.

Conclusions:

  • Copper levels are elevated in uremia irrespective of dialysis treatment.
  • The observed hypercupremia in uremia is not attributable to increased plasma ceruloplasmin.
  • The findings suggest an alternative mechanism for copper elevation in uremic patients.