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RNA-seq

RNA-seq

RNA sequencing, or RNA-Seq, is a high-throughput sequencing technology used to study the transcriptome of a cell. Transcriptomics helps to interpret the functional elements of a genome and identify the molecular constituents of an organism. Additionally, it also helps in understanding the development of an organism and the occurrence of diseases.
Before the discovery of RNA-seq, microarray-based methods and Sanger sequencing were used for transcriptome analysis. However, while...

Hair Cells

Hair Cells

Hair cells are the sensory receptors of the auditory system—they transduce mechanical sound waves into electrical energy that the nervous system can understand. Hair cells are located in the organ of Corti within the cochlea of the inner ear, between the basilar and tectorial membranes. The actual sensory receptors are called inner hair cells. The outer hair cells serve other functions, such as sound amplification in the cochlea, and are not discussed in detail here.

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Related Experiment Video

Updated: Nov 16, 2025

Author Spotlight: Dissection of Adult Mouse Stria Vascularis for Single-Nucleus Sequencing or Immunostaining

Author Spotlight: Dissection of Adult Mouse Stria Vascularis for Single-Nucleus Sequencing or Immunostaining

Published on: April 21, 2023

Single-Cell Sequencing Applications in the Inner Ear.

Mingxuan Wu¹, Mingyu Xia¹, Wenyan Li¹

¹ENT Institute and Department of Otorhinolaryngology, Eye and ENT Hospital, State Key Laboratory of Medical Neurobiology and MOE Frontiers Center for Brain Science, Fudan University, Shanghai, China.

Frontiers in Cell and Developmental Biology

|March 1, 2021

Summary

This summary is machine-generated.

Single-cell sequencing (SCS) overcomes inner ear research challenges, revealing cellular diversity and developmental pathways. This technology enables deeper understanding of the delicate inner ear structure and its cell types.

Keywords:

hair cell inner ear single cell sequencing spiral ganglion neuron supporting cell

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Area of Science:

Genomics
Cell Biology
Otolaryngology

Background:

Inner ear genomics research is hindered by cell scarcity and structural complexity.
Previous methods could not resolve gene expression within specific inner ear cell populations.

Purpose of the Study:

To review recent advancements in inner ear research utilizing single-cell sequencing (SCS).
To highlight SCS's role in dissecting inner ear cellular heterogeneity and developmental processes.

Main Methods:

Review of recent studies employing single-cell sequencing (SCS) in inner ear research.
Analysis of gene expression patterns at the single-cell level.

Main Results:

SCS has successfully delineated tissue heterogeneity in the inner ear.
Identification of previously unknown cell subtypes and novel cell markers.
Unveiling of dynamic signaling pathways involved in inner ear development.

Conclusions:

Single-cell sequencing (SCS) is a transformative technology for inner ear research.
SCS provides unprecedented resolution for studying cell types and developmental dynamics.
Further exploration of SCS applications promises significant breakthroughs in understanding inner ear biology.