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Global, Regional, and National Burden of Myocarditis and Cardiomyopathy, 1990-2017

Haijiang Dai1,2, Dor Lotan3,4, Arsalan Abu Much3,4

  • 1Department of Cardiology, The Third Xiangya Hospital, Central South University, Changsha, China.

Frontiers in Cardiovascular Medicine
|March 1, 2021
PubMed

Insights

Myocarditis (MC), alcoholic cardiomyopathy (AC), and other cardiomyopathy (OC) represent significant global health challenges. Despite decreasing age-standardized rates, the overall number of cases, deaths, and disability increased from 1990 to 2017.

Area of Science:

  • Cardiology
  • Public Health
  • Epidemiology

Background:

  • Cardiomyopathies, including myocarditis (MC), alcoholic cardiomyopathy (AC), and other cardiomyopathy (OC), represent a significant global health burden.
  • Understanding the epidemiological trends and geographical variations of these conditions is crucial for public health interventions.

Purpose of the Study:

  • To estimate the global burden of myocarditis (MC), alcoholic cardiomyopathy (AC), and other cardiomyopathy (OC) from 1990 to 2017.
  • To analyze age-standardized rates and overall numbers of prevalent cases, deaths, years lived with disability (YLDs), and years of life lost (YLLs).

Main Methods:

  • Utilized data from the Global Burden of Disease study 2017, covering 195 countries and territories.
  • Employed a Cause of Death Ensemble model and Bayesian mixed-effects meta-regression for burden estimation.
  • Presented estimates as counts, age-standardized rates per 100,000 people, and percentage changes with 95% uncertainty intervals.

Main Results:

  • In 2017, MC, AC, and OC resulted in 1.80M, 1.62M, and 4.21M cases, respectively, with significant associated deaths and disability.
  • Globally, YLDs were 131,376 (MC), 139,087 (AC), and 353,325 (OC); YLLs were 1.26M (MC), 2.84M (AC), and 5.51M (OC).
  • Significant geographic variations in age-standardized rates for prevalence, death, YLDs, and YLLs were observed, with notable differences across countries.

Conclusions:

  • Myocarditis, alcoholic cardiomyopathy, and other cardiomyopathies are substantial global public health issues with increasing overall burden.
  • Significant geographic disparities in disease burden necessitate tailored public health strategies and resource allocation.
  • Further research into risk factors and improved prevention, early detection, and treatment strategies are warranted.

Keywords:
cardiomyopathyglobal burden of diseasemortalitymyocarditisprevalence

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