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Related Experiment Videos

Accuracy, continuity, and pattern of flow from five macrorate infusion pumps.

R D Leff1, J C Stull

  • 1Division of Clinical/Hospital Pharmacy, College of Pharmacy, University of Iowa, Iowa City 52242.

American Journal of Hospital Pharmacy
|February 1, 1988
PubMed
Summary

Five infusion pumps maintained accuracy within 5%, but pump type significantly impacted flow continuity. Different pump mechanisms create unique flow patterns, affecting drug delivery consistency.

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Area of Science:

  • Biomedical Engineering
  • Pharmacology

Background:

  • Accurate drug delivery is critical in patient care.
  • Infusion pumps are widely used for intravenous fluid and medication administration.
  • Understanding infusion pump performance is essential for safe and effective therapy.

Purpose of the Study:

  • To evaluate the accuracy, continuity, and flow patterns of commercial macrorate infusion pumps in vitro.
  • To determine the influence of pump type, flow rate, and sample collection time on flow continuity.

Main Methods:

  • In vitro testing of five macrorate infusion pumps at 5, 10, and 50 mL/hr.
  • Serial weight measurements using a computerized gravimetric technique.
  • Calculation of flow continuity using the coefficient of variance.

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Main Results:

  • All pumps demonstrated flow rates within 5% of the target rates.
  • Flow continuity varied significantly between different pump types.
  • Flow rate and sample collection time did not significantly affect flow continuity.
  • Each pump exhibited a unique flow pattern.

Conclusions:

  • The operating mechanism of infusion pumps influences drug delivery continuity.
  • Variations in flow continuity should be considered when interpreting clinical responses to continuous infusions.
  • Further in vitro and in vivo studies are needed to assess clinical significance.