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Related Concept Videos

Acute Coronary Syndrome II: Pathophysiology and Clinical Manifestations01:19

Acute Coronary Syndrome II: Pathophysiology and Clinical Manifestations

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The pathophysiology of Acute Coronary Syndrome [ACD] involves several key processes:The main underlying cause of ACD is atherosclerosis, a chronic inflammatory disease characterized by the buildup of lipid-laden plaques within the coronary arteries.As the atherosclerotic plaque grows in the coronary artery, it may become unstable due to the formation of a lipid-rich core and a thin fibrous cap. Inflammatory cells within the plaque, such as macrophages, secrete enzymes that degrade the...
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Acute Coronary Syndrome I: Introduction01:30

Acute Coronary Syndrome I: Introduction

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Acute Coronary Syndrome (ACS) encompasses a spectrum of heart conditions caused by sudden obstruction of coronary arteries, typically resulting from the rupture of an atherosclerotic plaque and subsequent thrombus (blood clot) formation. This obstruction can lead to partial or complete blockage of blood flow, causing varying degrees of myocardial ischemia or infarction.ACS includes the following clinical entities:Unstable Angina (UA)Non-ST-Elevation Myocardial Infarction (NSTEMI)ST-Elevation...
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Acute Coronary Syndrome III: Diagnostic Studies01:30

Acute Coronary Syndrome III: Diagnostic Studies

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Diagnosing acute coronary syndrome or ACS begins with a thorough patient history. Notable symptoms include central, crushing chest pain radiating to the left arm, neck, jaw, or back, along with shortness of breath, sweating (diaphoresis), nausea, vomiting, dizziness, and palpitations.It is crucial to note any history of cardiac illnesses and assess risk factors, including age, gender, smoking, hypertension, diabetes, hyperlipidemia, and a sedentary lifestyle.During physical examination, vital...
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Myocarditis II: Clinical Features and Diagnostic Tests01:27

Myocarditis II: Clinical Features and Diagnostic Tests

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Myocarditis is an inflammation of the heart muscle. The symptoms vary widely, encompassing asymptomatic presentations to severe, acute manifestations.Clinical PresentationAsymptomatic cases: In some instances, myocarditis may be asymptomatic, with the infection resolving without intervention. These cases often go undetected unless discovered incidentally through diagnostic imaging or tests conducted for other reasons.General Early Symptoms: Early symptoms of myocarditis are non-specific and can...
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Coronary Artery Disease III: Clinical Manifestations01:30

Coronary Artery Disease III: Clinical Manifestations

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Coronary Artery Disease (CAD) is a primary health risk worldwide, leading to significant morbidity and mortality. The condition arises from the buildup of atherosclerotic plaques within the coronary arteries, resulting in diminished blood supply to the heart muscle.The clinical manifestations of CAD vary widely, from asymptomatic stages to severe, life-threatening conditions. Understanding these manifestations is crucial for early diagnosis and effective management.Angina Pectoris: The Warning...
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Electrocardiogram01:29

Electrocardiogram

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An electrocardiogram (ECG or EKG) is a critical diagnostic tool that records the electrical signals produced by the heart during each heartbeat. This recording is achieved through electrodes placed strategically on the arms, legs, and chest. The electrocardiograph amplifies these signals and produces 12 distinct tracings, offering a comprehensive understanding of the heart's electrical activity.
Three major waveforms are present in a typical ECG recording: the P wave, the QRS complex, and...
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A Research Method For Detecting Transient Myocardial Ischemia In Patients With Suspected Acute Coronary Syndrome Using Continuous ST-segment Analysis
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ST-segment elevation in patients presenting with COVID-19: case series.

Mehrdad Saririan1, Richard Armstrong2, Jon C George3

  • 1Division of Cardiology, Valleywise Health/Creighton University, Phoenix, AZ, USA.

European Heart Journal. Case Reports
|March 1, 2021
PubMed
Summary

Patients with COVID-19 may experience ST-segment elevation myocardial infarction (STEMI) symptoms without blocked arteries. Further research is needed to understand this cardiac manifestation of coronavirus disease (COVID-19).

Keywords:
COVID-19Case reportCase seriesHistologySTEMI

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Area of Science:

  • Cardiology
  • Infectious Diseases
  • Pathology

Background:

  • Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causes coronavirus disease (COVID-19).
  • Emerging reports suggest COVID-19 patients may exhibit symptoms of ST-segment elevation myocardial infarction (STEMI) without coronary artery occlusion.

Observation:

  • An international case series of patients with confirmed COVID-19 infection presenting with suspected STEMI was analyzed.
  • Three COVID-19 patients met electrocardiogram criteria for STEMI.
  • Coronary angiography revealed no obstructive coronary disease in these patients.
  • Post-mortem histology in one case showed myocardial ischemia without coronary atherothrombosis or myocarditis.

Findings:

  • COVID-19 patients can present with STEMI-like features and patent coronary arteries.
  • Myocardial ischemia can occur in the absence of typical coronary artery disease.

Implications:

  • This presentation highlights a potential novel cardiac complication of COVID-19.
  • Systematic investigation is required to determine the prevalence and clinical outcomes of this condition.
  • Understanding this association is crucial for patient management and public health strategies during the pandemic.