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Related Experiment Video

Updated: Nov 15, 2025

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[A novel flavanone from Thymus przewalskii].

Xiao-Qiang Chang1, Yue Ma1, Peng Sun1

  • 1Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences Beijing 100700, China Artemisinin Research Center, China Academy of Chinese Medical Sciences Beijing 100700, China.

Zhongguo Zhong Yao Za Zhi = Zhongguo Zhongyao Zazhi = China Journal of Chinese Materia Medica
|March 1, 2021
PubMed
Summary

Four flavanones were isolated from Thymus przewalskii, including one new compound. These compounds showed weak cytotoxicity against human lung cancer cells (A549).

Keywords:
Thymus przewalskiichemical constituentscytotoxicityflavanone

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Area of Science:

  • Phytochemistry
  • Natural Products Chemistry
  • Pharmacology

Background:

  • Thymus przewalskii is a plant species with potential medicinal properties.
  • Investigating its chemical constituents can lead to the discovery of novel bioactive compounds.

Purpose of the Study:

  • To isolate and identify chemical constituents from the aerial parts of Thymus przewalskii.
  • To evaluate the cytotoxic activity of the isolated compounds against human lung cancer cells.

Main Methods:

  • Extraction and isolation using column chromatography (silica gel, ODS, Sephadex LH-20) and semi-preparative HPLC.
  • Structure elucidation through physicochemical properties and spectroscopic data (including CD spectra).
  • Cytotoxicity assay using human lung cancer cell line A549.

Main Results:

  • Four flavanones were isolated: (2S)-5,6-dihydroxy-7,8,4'-trimethoxyflavanone (new), 5,4'-dihydroxy-6,7-dimethoxyflavanone (new to Thymus genus), (2S)-5,4'-dihydroxy-7,8-dimethoxyflavanone (new natural product), and sakuranetin (new to T. przewalskii).
  • Compound 1 is a novel flavanone, and compounds 1 and 3 had their configurations determined by CD spectra.
  • The four isolated flavanones exhibited weak cytotoxicity against A549 cells, with IC50 values ranging from 74.5 to 135.6 μmol·L⁻¹.

Conclusions:

  • The study successfully identified four flavanones from Thymus przewalskii, expanding the knowledge of its chemical profile.
  • The isolated flavanones possess weak cytotoxic activity against human lung cancer cells, suggesting potential for further investigation.
  • This research contributes to understanding the phytochemical diversity and potential therapeutic applications of Thymus przewalskii.