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An Old Enemy: Still Nephrotoxic

Faruk Recep Ozalp1, Tugba Karadeniz2, Alper Alp3

  • 1Department of Internal Medicine, Izmir University of Health Sciences, Tepecik Training and Research Hospital, Izmir, Turkey.

Journal of the College of Physicians and Surgeons--Pakistan : JCPSP
|March 1, 2021
PubMed

Tubulointerstitial nephritis (TIN) presents histopathologically as tubulitis and oedema/inflammation and fibrosis, affecting the renal tubules and interstitium with relative sparing of the glomeruli and vasculature. It can be acute or chronic or acute on chronic and has a wide range of etiologies. In this article, we report a case of a 44-year male who presented with acute TIN, associated with the use of diclofenac at therapeutic doses, that resolved with treatment but later progressed to chronic TIN after the patient resumed diclofenac therapy. The case is discussed in the context of literature regarding the nephrotoxic effects of nonsteroidal anti-inflammatory drugs (NSAIDs). Key Words: Nonsteroidal anti-inflammatory drugs, Acute kidney injury, Tubulointerstitial nephritis.

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