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Liquid Filled Hard Shell Capsules: Current Drug Delivery Influencing Pharmaceutical Technology
Prabhuti Nirale1, Shivani Arora1, Anita Solanki2
1Shobhaben Pratapbhai Patel School of Pharmacy & Technology Management, SVKM's NMIMS (Deemed to be University), Mumbai, India.
Liquid-filled hard capsules offer a promising novel delivery system for drugs with poor solubility and low bioavailability. This technology enhances therapeutic potential and patient convenience for various drug molecules.
Area of Science:
- Pharmaceutical Sciences
- Drug Delivery Systems
Background:
- Gastric absorption is a preferred route for drug delivery due to convenience and efficacy.
- Many drugs exhibit poor solubility and low bioavailability, limiting their therapeutic effectiveness.
Purpose of the Study:
- To review innovations in liquid filling technology for hard-shell capsules.
- To explore the potential of liquid-filled hard capsules as a novel drug delivery system.
Main Methods:
- A comprehensive literature review, including patent analysis, was performed.
- Focused on advancements in technology, processes, and applications for liquid filling in hard-shell capsules.
Main Results:
- Liquid-filled hard capsules are crucial for complex and sensitive drug molecules (light/moisture).
- This technology supports both immediate and delayed drug release profiles.
- Band sealing enhances capsule integrity and tamper-evidence.
Conclusions:
- Liquid-filled hard capsules represent a significant advancement in formulation development.
- This technology improves therapeutic outcomes and patient convenience for diverse drug formulations.
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