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A Mini Review on the Pathogenesis, Diagnosis and Treatment Options for COVID-19

Farzad Rahmani1,2, Aghigh Ziaeemehr2, Sajede Alijannejad3

  • 1Student Research Committee, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.

Infectious Disorders Drug Targets
|March 1, 2021
PubMed

Insights

The COVID-19 pandemic, caused by SARS-CoV-2, urgently needs new treatments. This review covers symptoms, pathogenesis, and current therapeutic strategies for managing this global health crisis.

Area of Science:

  • Virology
  • Immunology
  • Public Health

Background:

  • Coronavirus disease 2019 (COVID-19), caused by SARS-CoV-2, is a severe global health crisis with high morbidity and mortality.
  • Current treatment options for COVID-19 are limited, with no specific antiviral drugs approved.
  • Severe COVID-19 cases can lead to fatal complications like cytokine storm and acute respiratory distress syndrome.

Purpose of the Study:

  • To provide a comprehensive overview of COVID-19 symptoms and pathogenesis.
  • To summarize existing and emerging therapeutic strategies for managing SARS-CoV-2 infection.
  • To highlight the urgent need for novel therapeutic approaches to improve patient outcomes.

Main Methods:

  • This mini-review synthesizes information from existing literature.
  • It summarizes key aspects of COVID-19 symptoms and disease progression.
  • It reviews current therapeutic interventions and their limitations.

Main Results:

  • COVID-19 presents with a range of symptoms and its pathogenesis involves complex immune responses.
  • The cytokine storm and acute respiratory distress syndrome are critical factors in severe cases.
  • Existing therapeutic approaches are insufficient, underscoring the need for new treatments.

Conclusions:

  • Effective management of COVID-19 requires a deeper understanding of its pathogenesis.
  • Novel therapeutic strategies are crucial for controlling SARS-CoV-2 spread and improving patient survival.
  • Further research into antiviral agents and immunomodulatory therapies is essential.
Keywords:
COVID-19SARS-CoV-2Viral infectionanosmiadiagnosispathogenesis

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