Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Using Imaris to rigorously track PET-defined sites of lung inflammation in <i>Mycobacterium tuberculosis</i>-exposed non-human primates.

American journal of diagnostic imaging·2026
Same author

A radiopharmaceutical enhances CAR T cells against radio-sensitive and radio-resistant neuroblastoma by tumor sensitization and TME remodeling.

Cell reports. Medicine·2026
Same author

Tilmanocept Labels Granulomas in Cardiac Sarcoidosis.

Journal of cardiac failure·2026
Same author

pH-responsive substrate switching in mycobacterial type VII ESX secretion.

mSphere·2026
Same author

Musculoskeletal imaging findings of xylazine-associated wounds.

Emergency radiology·2026
Same author

Host-directed nanotherapy for the treatment and imaging of tuberculous meningitis.

Theranostics·2026

Related Experiment Video

Updated: Nov 15, 2025

Analysis of 18FDG PET/CT Imaging as a Tool for Studying Mycobacterium tuberculosis Infection and Treatment in Non-human Primates
10:04

Analysis of 18FDG PET/CT Imaging as a Tool for Studying Mycobacterium tuberculosis Infection and Treatment in Non-human Primates

Published on: September 5, 2017

19.0K

Visualizing the dynamics of tuberculosis pathology using molecular imaging.

Alvaro A Ordonez1,2,3, Elizabeth W Tucker1,2,4, Carolyn J Anderson5

  • 1Center for Infection and Inflammation Imaging Research.

The Journal of Clinical Investigation
|March 1, 2021
PubMed
Summary

Molecular imaging offers new ways to study tuberculosis (TB) by visualizing Mycobacterium tuberculosis infections in 3D and over time. This technology can improve understanding and accelerate the development of new TB diagnostics and treatments.

More Related Videos

Imaging Mycobacterium tuberculosis in Mice with Reporter Enzyme Fluorescence
10:06

Imaging Mycobacterium tuberculosis in Mice with Reporter Enzyme Fluorescence

Published on: February 26, 2018

7.6K
A 3D Human Lung Tissue Model for Functional Studies on Mycobacterium tuberculosis Infection
10:10

A 3D Human Lung Tissue Model for Functional Studies on Mycobacterium tuberculosis Infection

Published on: October 5, 2015

19.2K

Related Experiment Videos

Last Updated: Nov 15, 2025

Analysis of 18FDG PET/CT Imaging as a Tool for Studying Mycobacterium tuberculosis Infection and Treatment in Non-human Primates
10:04

Analysis of 18FDG PET/CT Imaging as a Tool for Studying Mycobacterium tuberculosis Infection and Treatment in Non-human Primates

Published on: September 5, 2017

19.0K
Imaging Mycobacterium tuberculosis in Mice with Reporter Enzyme Fluorescence
10:06

Imaging Mycobacterium tuberculosis in Mice with Reporter Enzyme Fluorescence

Published on: February 26, 2018

7.6K
A 3D Human Lung Tissue Model for Functional Studies on Mycobacterium tuberculosis Infection
10:10

A 3D Human Lung Tissue Model for Functional Studies on Mycobacterium tuberculosis Infection

Published on: October 5, 2015

19.2K

Area of Science:

  • Microbiology
  • Infectious Diseases
  • Medical Imaging

Background:

  • Tuberculosis (TB), caused by Mycobacterium tuberculosis, remains a significant global health threat.
  • The complex host-pathogen interactions in TB lead to poorly understood disease states, from latent to active infection.
  • Current diagnostic tools struggle to capture the spatiotemporal dynamics and distinct pathologies within a single TB-infected subject.

Purpose of the Study:

  • To highlight the potential of next-generation molecular imaging in TB research.
  • To emphasize the ability of molecular imaging to provide holistic, 3D spatial characterization of infection.
  • To showcase the noninvasive, temporal monitoring capabilities of molecular imaging within subjects.

Main Methods:

  • Review of next-generation molecular imaging technologies applicable to infectious diseases.
  • Discussion of how these imaging techniques can visualize Mycobacterium tuberculosis.
  • Exploration of the application of molecular imaging for monitoring disease progression and treatment response.

Main Results:

  • Next-generation molecular imaging provides unparalleled opportunities for visualizing TB infection.
  • These techniques offer holistic, 3D spatial characterization of infection.
  • Noninvasive, temporal monitoring within the same subject is achievable, overcoming limitations of current tools.

Conclusions:

  • Molecular imaging can significantly advance fundamental knowledge of TB pathogenesis.
  • This technology has the potential to accelerate the development of novel TB diagnostics and therapeutics.
  • Enhanced visualization and monitoring through molecular imaging are crucial for combating TB.