Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

¹³C NMR: Distortionless Enhancement by Polarization Transfer (DEPT)01:20

¹³C NMR: Distortionless Enhancement by Polarization Transfer (DEPT)

1.3K
When proton-coupled carbon-13 spectra are simplified by a broadband proton decoupling technique, structural information about the coupled protons is lost. Distortionless enhancement by polarization transfer (DEPT) is a technique that provides information on the number of hydrogens attached to each carbon in a molecule. While the DEPT experiment utilizes complex pulse sequences, the pulse delay and flip angle are specifically manipulated. The resulting signals have different phases depending on...
1.3K
Improving Translational Accuracy02:07

Improving Translational Accuracy

12.4K
Base complementarity between the three base pairs of mRNA codon and the tRNA anticodon is not a failsafe mechanism. Inaccuracies can range from a single mismatch to no correct base pairing at all. The free energy difference between the correct and nearly correct base pairs can be as small as 3 kcal/ mol. With complementarity being the only proofreading step, the estimated error frequency would be one wrong amino acid in every 100 amino acids incorporated. However, error frequencies observed in...
12.4K
Improving Translational Accuracy02:07

Improving Translational Accuracy

3.3K
3.3K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Revisiting the auditory hemodynamic response function in the era of fast fMRI.

bioRxiv : the preprint server for biology·2026
Same author

Reducing Motion Artifact in High Resolution 7 T MRI Using the Magnetic Resonance Minimal Motion ("MR-MinMo") Head Stabilization Device.

Magnetic resonance in medicine·2026
Same author

Neuronal plasticity during motor rehabilitation training after spinal cord injury.

Communications biology·2026
Same author

Evidence for divergent cortical organisation in Parkinson's disease and Lewy Body Dementia.

Nature communications·2025
Same author

ISME-incoherent sampling of multi-echo data to minimize cardiac-induced noise in brain maps of <math><semantics><mrow><msubsup><mi>R</mi> <mn>2</mn> <mo>*</mo></msubsup></mrow> <annotation>$$ {R}_2^{\ast } $$</annotation></semantics></math> and magnetic susceptibility.

Magnetic resonance in medicine·2025
Same author

Communication of perceptual predictions from the hippocampus to the deep layers of the parahippocampal cortex.

Science advances·2025

Related Experiment Video

Updated: Nov 15, 2025

Quantitative Magnetic Resonance Imaging of Skeletal Muscle Disease
09:30

Quantitative Magnetic Resonance Imaging of Skeletal Muscle Disease

Published on: December 18, 2016

19.8K

Imperfect spoiling in variable flip angle T1 mapping at 7T: Quantifying and minimizing impact.

Nadège Corbin1, Martina F Callaghan1

  • 1Wellcome Centre for Human Neuroimaging, UCL Queen Square Institute of Neurology, University College London, London, United Kingdom.

Magnetic Resonance in Medicine
|March 1, 2021
PubMed
Summary

Accurate T1 mapping using variable flip angle (VFA) requires optimizing radiofrequency (RF) and gradient spoiling. This study reveals how to minimize T1 errors by carefully selecting RF and gradient parameters, considering diffusion effects for improved accuracy at 7T.

Keywords:
7TEPGMPMT1 mappingVFAimperfect spoiling

More Related Videos

Author Spotlight: Using Hyperpolarized Xenon-129 MRI to Study Lung Diseases
09:55

Author Spotlight: Using Hyperpolarized Xenon-129 MRI to Study Lung Diseases

Published on: January 5, 2024

1.6K
Assessment of Cardiac Function and Myocardial Morphology Using Small Animal Look-locker Inversion Recovery SALLI MRI in Rats
08:41

Assessment of Cardiac Function and Myocardial Morphology Using Small Animal Look-locker Inversion Recovery SALLI MRI in Rats

Published on: July 19, 2013

12.9K

Related Experiment Videos

Last Updated: Nov 15, 2025

Quantitative Magnetic Resonance Imaging of Skeletal Muscle Disease
09:30

Quantitative Magnetic Resonance Imaging of Skeletal Muscle Disease

Published on: December 18, 2016

19.8K
Author Spotlight: Using Hyperpolarized Xenon-129 MRI to Study Lung Diseases
09:55

Author Spotlight: Using Hyperpolarized Xenon-129 MRI to Study Lung Diseases

Published on: January 5, 2024

1.6K
Assessment of Cardiac Function and Myocardial Morphology Using Small Animal Look-locker Inversion Recovery SALLI MRI in Rats
08:41

Assessment of Cardiac Function and Myocardial Morphology Using Small Animal Look-locker Inversion Recovery SALLI MRI in Rats

Published on: July 19, 2013

12.9K

Area of Science:

  • Magnetic Resonance Imaging
  • Quantitative MRI

Background:

  • The variable flip angle (VFA) method for T1 mapping relies on the assumption of perfectly spoiled transverse magnetization after each repetition time (TR).
  • Imperfect spoiling, despite radiofrequency (RF) and gradient spoiling, leads to inaccuracies in T1 estimates.
  • Existing theoretical corrections often assume a global T2 time, which may not reflect actual tissue properties.

Purpose of the Study:

  • To investigate the impact of imperfect spoiling on T1 mapping accuracy at 7 Tesla (7T).
  • To examine the interplay between RF and gradient spoiling conditions, including the influence of diffusion.
  • To provide practical guidance for optimizing T1 estimation in 3D multi-echo acquisitions.

Main Methods:

  • Numerical simulations were employed to model the effects of spoiling regimes.
  • Phantom experiments were conducted to validate simulation findings.
  • In vivo experiments were performed to assess the impact in biological tissues.

Main Results:

  • The study confirmed the predicted dependency of T1 errors on tissue properties, system parameters, and spoiling conditions in both phantom and in vivo data.
  • Diffusion effects were found to influence the relationship between T1 error, RF spoiling efficiency, and T2 times.
  • The interaction between RF and gradient spoiling significantly impacts T1 accuracy.

Conclusions:

  • Minimizing T1 errors involves selecting specific RF spoiling increments and gradient spoiler moments to reduce T2 dependence and maintain image quality.
  • While diffusion effects are minor at 7T, incorporating correction factors is advisable for enhanced accuracy.
  • Optimized spoiling strategies are crucial for reliable T1 mapping.