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Prolonged anaesthesia with isoflurane and halothane. Effects on hepatic function.

J P Jantzen¹, P P Kleemann, P K Witton

¹Department of Anaesthesiology, Johannes Gutenberg University Medical School, Mainz, Federal Republic of Germany.

|March 1, 1988

Summary

Isoflurane anesthesia is safer for liver function than halothane anesthesia during prolonged maxillofacial surgery. This study found isoflurane caused fewer negative impacts on liver synthetic function compared to halothane.

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Area of Science:

Anesthesiology
Hepatology
Surgical Science

Background:

Prolonged maxillofacial surgery requires careful anesthetic management.
Assessing anesthetic impact on liver function is crucial for patient safety.

Purpose of the Study:

To compare the effects of isoflurane and halothane anesthesia on hepatic function.
To evaluate liver synthetic function following prolonged maxillofacial surgery.

Main Methods:

Hepatic function was assessed in 40 patients pre-operatively and on postoperative days 1 and 6.
Measurements included hepatic enzymes, bilirubin, one-stage prothrombin time, and Factor VII concentrations.
Patients received either isoflurane or halothane anesthesia.

Main Results:

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No significant changes in hepatic enzymes or bilirubin were observed between anesthetic groups.
A decrease in one-stage prothrombin time and Factor VII was noted on postoperative day 1.
This decrease was more pronounced in patients who received halothane anesthesia.

Conclusions:

Isoflurane appears to be a preferable anesthetic agent over halothane for prolonged maxillofacial surgery.
Isoflurane better preserves the liver's synthetic function compared to halothane.