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Updated: Jun 22, 2026

Hollow Microneedle-based Sensor for Multiplexed Transdermal Electrochemical Sensing
08:19

Hollow Microneedle-based Sensor for Multiplexed Transdermal Electrochemical Sensing

Published on: June 1, 2012

Lab under the Skin: Microneedle Based Wearable Devices.

Hazhir Teymourian1, Farshad Tehrani1, Kuldeep Mahato1

  • 1Department of Nanoengineering, University of California San Diego, La Jolla, CA, 92093, USA.

Advanced Healthcare Materials
|March 1, 2021
PubMed
Summary

New microneedle sensors extract dermal interstitial fluid (ISF) for real-time molecular health monitoring. These wearable biosensors offer continuous chemical analysis, advancing personalized diagnostics despite current challenges.

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Area of Science:

  • Biomedical Engineering
  • Wearable Technology
  • Biosensors

Background:

  • Current wearables track mobility and vitals, but lack molecular-level health insights.
  • Dermal interstitial fluid (ISF) is a rich source of clinical indicators, accessible via painless microneedle extraction.
  • Microneedle sensors are emerging as key devices for transdermal health monitoring.

Purpose of the Study:

  • To review the progress, trends, and capabilities of microneedle-empowered sensors for molecular-level health monitoring.
  • To identify current challenges and propose a future roadmap for commercializing these advanced wearable devices.

Main Methods:

  • Review of recent advancements in microneedle-based transdermal sensor technology.
  • Focus on electrochemical biosensors integrated with microneedles for direct chemical measurements.
Keywords:
closed-loop systemcontinuous monitoringmicroneedlesmultiplexed detectionwearable biosensors

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Last Updated: Jun 22, 2026

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Published on: June 1, 2012

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  • Analysis of ISF extraction and analysis techniques (on-chip and off-chip).

    • Main Results:

    • Significant progress in real-time monitoring of metabolites, electrolytes, and therapeutics using microneedle sensors.
    • Advancements in simultaneous, multiplexed detection of multiple chemical markers.
    • Development of microneedle electrochemical biosensors for direct, continuous chemical measurements.

    Conclusions:

    • Microneedle-based sensors are poised to revolutionize personalized health monitoring by enabling molecular-level insights from ISF.
    • Despite advancements, significant challenges remain in translating these innovations into commercial products.
    • A clear roadmap is needed to overcome hurdles and bring microneedle sensor technology to market.