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Updated: Nov 15, 2025

Author Spotlight: Unveiling Transmembrane Protein Family-Related Markers in Gastric Cancer and Implications for Targeted Therapies
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The PI3K/Akt/mTOR signaling pathway in gastric cancer; from oncogenic variations to the possibilities for

Ayda Baghery Saghchy Khorasani1, Atieh Pourbagheri-Sigaroodi2, Ali Pirsalehi3

  • 1Department of Hematology, School of Medical Sciences, Tarbiat Modares University, Tehran, Iran.

European Journal of Pharmacology
|March 1, 2021
PubMed

Insights

Investigating the PI3K/Akt/mTOR pathway reveals its crucial role in gastric cancer (GC) development. Targeting this pathway offers promising therapeutic strategies for this fatal malignancy.

Area of Science:

  • Oncology
  • Molecular Biology
  • Cancer Pathogenesis

Background:

  • Genetic and epigenetic alterations are key in cancer, but convergence into malignancy is complex.
  • Signaling cascades regulating cell survival and metabolism are implicated in cancer formation.
  • The phosphatidylinositol-3-kinase (PI3K) pathway is frequently activated in human cancers.

Purpose of the Study:

  • To elucidate the role of the PI3K/Akt/mTOR axis in gastric cancer (GC) pathogenesis.
  • To explore therapeutic strategies targeting the PI3K/Akt/mTOR axis in GC.

Main Methods:

  • Review of existing literature on genetic/epigenetic alterations in cancer.
  • Analysis of signaling pathways involved in cell survival and metabolism.
  • Focus on the PI3K/Akt/mTOR axis and its prevalence in gastric cancer.

Main Results:

  • The PI3K/Akt/mTOR axis is significantly implicated in the pathogenesis of gastric cancer.
  • Aberrant molecules within this cascade contribute to cancer cell viability and proliferation.
  • This pathway is activated in approximately one-third of all human cancers.

Conclusions:

  • The PI3K/Akt/mTOR axis is a critical player in gastric cancer development.
  • Inhibitors of this axis represent a potential therapeutic avenue for gastric cancer treatment.
Keywords:
Gastric cancerPI3K/Akt/mTOR pathwayPTENPhosphatidylinositol-3-kinase

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