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Updated: Nov 15, 2025

Determining Immune System Suppression versus CNS Protection for Pharmacological Interventions in Autoimmune Demyelination
Published on: September 12, 2016
Defining the disease course of TNFα blockers-associated Multiple Sclerosis
Matteo Lucchini1, Guido Maria Giuffrè1, Viviana Nociti1
1Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Rome, Italy; Istituto di Neurologia, Università Cattolica del Sacro Cuore, Rome, Italy.
Abstract:
Tumour Necrosis Factor alpha (TNFα) blockers are common and effective treatments for several autoimmune diseases but can be associated with neuroinflammatory events. We describe the disease course of ten patients who developed CNS demyelinating events while exposed to TNFα blockers. We divided them into two groups: eight patients with Relapsing Multiple Sclerosis and two isolated optic neuritis. In our cohort, TNFα blockers-associated Multiple Sclerosis does not seem to be associated with a more aggressive course and can be managed with MS-specific DMTs, chosen considering the clinical course and the concomitant autoimmune disease. Our findings need confirmation in larger cohorts to further characterize the disease course of TNFα blockers-associated Multiple Sclerosis.
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