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Assessment of Vascular Function in Patients With Chronic Kidney Disease
08:50

Assessment of Vascular Function in Patients With Chronic Kidney Disease

Published on: June 16, 2014

16.5K

[Kidney as pacemaker for cardiovascular aging]

Christoph Wanner, Jan Galle, Kai Lopau

    Deutsche Medizinische Wochenschrift (1946)
    |March 1, 2021
    PubMed

    Insights

    Sodium-glucose cotransporter 2 (SGLT2) inhibitors protect kidneys and extend life for patients with type 2 diabetes and kidney disease. These drugs also benefit heart failure patients, with new multi-stage therapies showing complementary effects.

    Area of Science:

    • Nephrology
    • Cardiology
    • Endocrinology

    Background:

    • Kidney disease accelerates aging and is exacerbated by vascular risk factors.
    • Type 2 diabetes mellitus combined with kidney disease can reduce lifespan by up to 16 years.
    • Sodium-glucose cotransporter 2 (SGLT2) inhibitors are crucial for maintaining kidney function.

    Purpose of the Study:

    • To explore the role of SGLT2 inhibitors in promoting longevity in kidney patients.
    • To discuss the benefits of SGLT2 inhibitors in patients with type 2 diabetes and kidney disease.
    • To introduce a novel 3-stage therapy for heart failure incorporating SGLT2 inhibitors.

    Main Methods:

    • Inhibition of the SGLT2 transporter in the kidney's proximal tubule.
    • Induction of a hypometabolic state through continuous excretion of energy and water.
    • Combination therapy involving beta blockers, SGLT2 inhibitors, angiotensin receptor/neprilysin inhibitors, and mineralocorticoid receptor antagonists.

    Main Results:

    • SGLT2 inhibition supports organ function and promotes longevity.
    • Kidney protection via SGLT2 inhibitors extends life expectancy in type 2 diabetes patients.
    • A multi-stage therapeutic approach for heart failure demonstrates complementary effects.

    Conclusions:

    • SGLT2 inhibitors offer significant benefits for kidney health and longevity, particularly in patients with type 2 diabetes.
    • The use of SGLT2 inhibitors is expanding to include heart failure management.
    • A sequential combination therapy involving SGLT2 inhibitors shows promise for comprehensive cardiovascular and renal protection.

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