Ocular and corneal aberrations changes in controlled randomized clinical trial MiSight® Assessment Study Spain (MASS)

Area of Science:

• Ophthalmology
• Optometry
• Vision Science

Background:

• Myopia control in children is a significant clinical challenge.
• Assessing the impact of myopia control interventions on ocular aberrations is crucial for understanding long-term visual health.
• MiSight contact lenses (CL) are designed for myopia control in pediatric populations.

Purpose of the Study:

• To compare ocular and corneal inherent aberrations in children using MiSight CL versus single-vision spectacles for myopia control over 24 months.
• To evaluate the longitudinal effects of myopia control strategies on visual aberrations.

Main Methods:

• A randomized trial involving children aged 8-12 years with myopia and astigmatism.
• Participants were assigned to either MiSight CL or single-vision spectacles.
• Aberrometry was used to measure various ocular and corneal aberrations (RMS, SA) at baseline, 12, and 24 months.

Main Results:

• 74 children completed the 24-month study.
• The MiSight group showed no significant changes in total ocular RMS (RMS_T) or corneal aberrations.
• The control group (single-vision spectacles) exhibited a significant increase in RMS_T after 24 months.

Conclusions:

• MiSight CL did not induce significant changes in corneal or total ocular RMS over two years.
• Single-vision spectacles resulted in significant changes in total ocular RMS, correlating with eye growth and myopia progression.
• These findings suggest MiSight CL may offer a stable visual aberration profile during myopia control treatment in children.