Towards personalised management for non-variceal upper gastrointestinal bleeding

Area of Science:

• Gastroenterology
• Internal Medicine

Background:

• Existing guidelines for upper gastrointestinal bleeding (UGIB) lack individualized patient management strategies.
• Optimal UGIB treatment necessitates consideration of patient-specific factors and healthcare setting resources.

Purpose of the Study:

• To integrate international guidelines and consensus for a personalized, staged approach to UGIB management.
• To provide a framework for decision-making in pre-endoscopic, endoscopic, and post-endoscopic phases of UGIB care.

Main Methods:

• Systematic integration of international professional society guidelines and expert consensus on UGIB.
• Development of a three-stage management framework: pre-endoscopic, endoscopic, and post-endoscopic.
• Emphasis on tailoring strategies based on patient characteristics, bleeding lesion type, and clinical environment.

Main Results:

• A comprehensive, three-stage management model for upper gastrointestinal bleeding.
• Identification of key factors for personalized treatment: patient status, bleeding source, and resource availability.
• Integration of current evidence into actionable clinical pathways.

Conclusions:

• Personalized management strategies are crucial for optimizing upper gastrointestinal bleeding treatment.
• A staged approach considering individual patient needs and resources improves clinical decision-making.
• This framework facilitates tailored care for diverse UGIB scenarios.