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Updated: Nov 15, 2025
07:46
Isolation, Characterization, and Purification of Macrophages from Tissues Affected by Obesity-related Inflammation
Published on: April 3, 2017
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Chronic tissue inflammation and metabolic disease
Yun Sok Lee1, Jerrold Olefsky1
1Department of Medicine, Division of Endocrinology and Metabolism, University of California at San Diego, La Jolla, California 92093, USA.
Genes & Development
|March 2, 2021
Summary
Obesity causes insulin resistance and type 2 diabetes (T2DM) through chronic inflammation. Understanding immunometabolism offers new therapeutic targets for metabolic dysfunction.
Area of Science:
- Immunometabolism
- Obesity research
- Inflammation biology
Background:
- Obesity is a primary driver of insulin resistance and type 2 diabetes (T2DM).
- Chronic, low-grade tissue inflammation is a key factor in obesity-related metabolic dysfunction.
- The interplay between immune responses and metabolic processes (immunometabolism) is crucial.
Purpose of the Study:
- To summarize recent advancements in understanding immunometabolism.
- To elucidate the mechanisms of chronic inflammation in metabolic tissues during obesity.
- To review current and novel immunomodulatory therapeutic strategies.
Main Methods:
- Review of recent scientific literature on immunometabolism and obesity.
- Analysis of inflammatory pathways in key metabolic tissues.
- Discussion of obesity-induced triggers like adipose tissue hypoxia and macrophage exosomes.
Main Results:
- Obesity triggers chronic inflammation in metabolic tissues.
- Adipose tissue hypoxia and macrophage-derived exosomes play significant roles.
- Current immunomodulatory therapies show promise.
Conclusions:
- Targeting immunometabolism is a promising approach for treating obesity-related insulin resistance and T2DM.
- Further research into inflammation mechanisms and exosome function is warranted.
- Immunomodulation offers potential for novel therapeutic interventions.
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