Covid Assossiated Invasive Fungal Sinusitis
Susan K Sebastian1, Vibhor B Kumar1, Manu Gupta2
1Department of ENT and Head and Neck Surgery, St. Stephen's Hospital, Tis Hazari, Delhi, 110054 India.
Summary
Acute invasive fungal sinusitis is a dangerous infection in immunocompromised individuals. COVID-19 patients face higher risks, as shown in three case reviews of fungal sinusitis linked to COVID-19.
Area of Science:
- Infectious Diseases
- Mycology
- Critical Care Medicine
Background:
- Acute invasive fungal sinusitis is a severe infection with high mortality, predominantly affecting immunocompromised patients.
- Patients with COVID-19 pneumonia exhibit diminished immunological competence, increasing susceptibility to opportunistic infections.
- Invasive fungal infections pose a significant threat in the context of COVID-19.
Purpose of the Study:
- To review and analyze three cases of invasive fungal sinusitis occurring in patients with COVID-19.
- To highlight the association between COVID-19 and invasive fungal sinusitis.
- To underscore the clinical presentation and management challenges of this co-infection.
Main Methods:
- Retrospective case series review.
- Analysis of clinical data, diagnostic findings, and treatment outcomes for three patients.
- Literature review on COVID-19 associated invasive fungal infections.
Main Results:
- Three cases of acute invasive fungal sinusitis were identified in patients with COVID-19.
- The patients presented with severe symptoms and required intensive management.
- Fungal sinusitis represents a serious complication in COVID-19 patients.
Conclusions:
- Invasive fungal sinusitis is a critical complication in immunocompromised patients with COVID-19.
- Early diagnosis and prompt treatment are essential for improving outcomes.
- Further research is needed to understand the pathogenesis and optimize management strategies.
More Related Videos
09:03Nasal Brushing Sampling and Processing Using Digital High Speed Ciliary Videomicroscopy – Adaptation for the COVID-19 Pandemic
Published on: November 7, 2020
5.2K
07:30Design of Cecal Ligation and Puncture and Intranasal Infection Dual Model of Sepsis-Induced Immunosuppression
Published on: June 15, 2019
10.3K
Related Concept Videos
01:29Fungal Group Zygomycota
589
Zygomycota, previously classified as a distinct fungal group, are primarily terrestrial, saprophytic molds that play a crucial role as decomposers. Recent phylogenetic studies have revealed that these fungi are now divided into two major clades — Mucoromycota, which includes many symbiotic species, and Zoopagomycota, which primarily consists of parasitic and pathogenic fungi. These groups exhibit distinct ecological roles and reproductive strategies while sharing key structural and...
589
01:24Cystic Fibrosis: Management
310
Cystic fibrosis (CF) is an autosomal recessive disorder that predominantly affects individuals of Northern European descent, occurring at a rate of 1 in 3500. It is caused by a genetic mutation in a gene on chromosome 7, most commonly the ΔF508 mutation, that codes for the cystic fibrosis transmembrane conductance regulator (CFTR) protein. This results in thicker mucus secretions and obstruction pathologies in multiple organs, including the lungs and sinuses.
Sinus disease and chronic...
Sinus disease and chronic...
310
01:28Fungal Phylum Microsporidia
256
Microsporidia are a group of obligate intracellular fungi that were initially classified as protists but were later reclassified based on phylogenetic, molecular, and structural evidence linking them to the Chytridiomycota. These unicellular, non-motile organisms are highly specialized parasites that infect a wide range of animal hosts, including humans. They have evolved extensive genomic and metabolic reductions, making them highly dependent on their hosts for survival.Morphology and Genomic...
256
01:30Pneumonia I: Introduction
493
Pneumonia is an acute respiratory infection that targets the lungs, specifically the alveoli. These tiny air sacs, essential for oxygen exchange, become engorged with pus and fluid, severely hindering breathing, decreasing oxygen absorption, and causing significant pain and discomfort during respiration.
Risk Factors
Various factors influence the likelihood of developing pneumonia. Age plays a crucial role, with infants, children under two, and individuals over 65 at increased risk due to their...
Risk Factors
Various factors influence the likelihood of developing pneumonia. Age plays a crucial role, with infants, children under two, and individuals over 65 at increased risk due to their...
493
01:25Endocarditis I: Introduction
167
Introduction:Endocarditis is the infection of the endocardium, the inner lining of the heart and its valves. When the heart muscle is involved, the condition is termed myocarditis, while an infection of the outer lining is called pericarditis. Infective endocarditis (IE) primarily affects the endocardium, where pathogens adhere to the valves or lining, forming vegetation that can lead to severe complications. Infective endocarditis occurs when microorganisms, usually bacteria from other body...
167
01:23Cystic Fibrosis: Pathogenesis
542
Cystic fibrosis (CF), an autosomal recessive disorder, significantly affects the function of exocrine glands. This genetically inherited disease is characterized by the production of thick and sticky mucus, which can severely affect various organs and systems in the body.
CF is primarily caused by a genetic mutation in a chromosome 7 gene coding for the cystic fibrosis transmembrane conductance regulator (CFTR) protein. The most common gene mutation leading to CF is the ΔF508 mutation,...
CF is primarily caused by a genetic mutation in a chromosome 7 gene coding for the cystic fibrosis transmembrane conductance regulator (CFTR) protein. The most common gene mutation leading to CF is the ΔF508 mutation,...
542