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Updated: Nov 15, 2025

Identification of Circular RNAs using RNA Sequencing
08:25

Identification of Circular RNAs using RNA Sequencing

Published on: November 14, 2019

12.5K

Functions of circular RNAs in bladder, prostate and renal cell cancer (Review)

Longfei Yang1, Xiaofeng Zou2, Junrong Zou3

  • 1First Clinical Medical College, Gannan Medical University, Ganzhou, Jiangxi 341000, P.R. China.

Molecular Medicine Reports
|March 2, 2021
PubMed

Insights

Circular RNAs (circRNAs) are crucial in urological cancers like bladder, prostate, and renal cell carcinoma. These non-coding RNAs show potential as diagnostic and prognostic biomarkers, though their functions require more research.

Area of Science:

  • Oncology
  • Molecular Biology
  • Genetics

Background:

  • Circular RNAs (circRNAs) are non-coding RNAs generated via back-splicing and exon-skipping.
  • circRNAs play roles in biological functions, including microRNA sponging and interaction with RNA-binding proteins.
  • These molecules are implicated in the progression of various cancer types.

Purpose of the Study:

  • To review recent research on the role of circRNAs in urological cancers.
  • To identify circRNAs involved in bladder cancer (BC), prostate cancer (PCa), and renal cell cancer (RCC).
  • To evaluate the potential of circRNAs as biomarkers for urological malignancies.

Main Methods:

  • Literature search of PubMed for articles published between November 2017 and September 2020.
  • Keywords used: 'Circular RNA (circRNA) AND bladder cancer (BC)', 'circular RNA (circRNA) AND prostate cancer (PCa)', 'circular RNA (circRNA) AND renal cell cancer (RCC)'.
  • Analysis of identified circRNAs and their targeted pathways.

Main Results:

  • >58 circRNAs were identified as implicated in urological cancers.
  • Several circRNAs target common cancer pathways like AKT, TGF-β, MAPK, and VEGF.
  • circRNAs are identified as modulators in BC, PCa, and RCC pathogenesis.

Conclusions:

  • circRNAs are significant modulators in bladder, prostate, and renal cell cancers.
  • circRNAs show potential as diagnostic and prognostic biomarkers for urological cancers.
  • Further research is needed to fully elucidate the functions of circRNAs in urinary system tumors.
Keywords:
circular RNAbladder cancerprostate cancerrenal cell cancer

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