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Updated: Nov 15, 2025

Identification of Circular RNAs using RNA Sequencing
08:25

Identification of Circular RNAs using RNA Sequencing

Published on: November 14, 2019

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Emerging roles of circular RNAs in non‑small cell lung cancer (Review)

Shanshan Li1, Yize Liu2, Guanzhen Qiu2

  • 1Department of Respiratory, Central Hospital Affiliated to Shenyang Medical College, Shenyang, Liaoning 110024, P.R. China.

Oncology Reports
|March 2, 2021
PubMed

Insights

Circular RNAs (circRNAs) regulate cancer progression and metastasis by interacting with microRNAs and proteins. These dysregulated circRNAs show potential as cancer biomarkers and therapeutic targets, especially in non-small cell lung cancer (NSCLC).

Area of Science:

  • Molecular Biology
  • Oncology
  • Genetics

Background:

  • Circular RNAs (circRNAs) are novel endogenous transcripts with regulatory roles in cellular processes.
  • CircRNAs function as crucial regulators in tumor development and metastasis by interacting with microRNAs and RNA-binding proteins.
  • Dysregulated circRNA expression is linked to advanced cancer stages and poorer patient survival.

Purpose of the Study:

  • To review the regulatory roles of circRNAs in the development and progression of non-small cell lung cancer (NSCLC).
  • To explore the potential of circRNAs as diagnostic and prognostic biomarkers for cancer.
  • To discuss circRNAs as potential therapeutic targets in NSCLC.

Main Methods:

  • Literature review of studies on circRNA function in cancer.
  • Analysis of circRNA involvement in key pathological processes like proliferation, apoptosis, invasion, and migration.
  • Evaluation of evidence linking circRNA expression to NSCLC progression and patient outcomes.

Main Results:

  • CircRNAs significantly influence tumor development, metastasis, proliferation, apoptosis, invasion, and migration in NSCLC.
  • Aberrant circRNA expression correlates with advanced Tumor-Node-Metastasis stage, lymph node status, and distant metastasis.
  • Specific circRNAs are associated with poor differentiation and reduced overall survival in cancer patients.

Conclusions:

  • CircRNAs play intricate roles in the pathological progression of NSCLC.
  • CircRNAs hold promise as valuable biomarkers for cancer diagnosis and prognosis.
  • Targeting circRNAs represents a potential therapeutic strategy for NSCLC.
Keywords:
circRNAsnon‑small cell lung cancercarcinogenesis

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