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Improving tumor budding reporting in colorectal cancer: a Delphi consensus study.

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Tumor budding, a key prognostic marker in colorectal cancer, now has standardized international reporting criteria (ITBCC). Further expert consensus clarifies its use and highlights research needs for improved patient care.

Keywords:
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Area of Science:

  • Gastrointestinal Pathology
  • Oncology
  • Cancer Research

Background:

  • Tumor budding is a recognized adverse prognostic indicator in colorectal cancer.
  • Previous methods for assessing tumor budding lacked standardization, leading to variability in reporting.
  • The International Tumor Budding Consensus Conference (ITBCC) aimed to establish a unified, evidence-based approach.

Framework:

  • The ITBCC criteria were developed through expert consensus to standardize tumor budding assessment.
  • These criteria have been validated in large patient cohorts.
  • The ITBCC guidelines are now integrated into international colorectal cancer pathology and clinical guidelines.

Implementation:

  • Wider adoption of ITBCC criteria has revealed new issues requiring clarification.
  • A modified Delphi process involving gastrointestinal pathology experts was used to address these emerging issues.
  • This process generated consensus on current challenges and identified areas for future research.

Implications:

  • This expert consensus reaffirms the clinical significance of tumor budding in colorectal cancer.
  • It supports the continued integration of tumor budding assessment into routine clinical practice.
  • Further research will refine understanding and application of tumor budding analysis for enhanced patient management.