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Related Experiment Videos

Infant feeding and allergy.

F G Miskelly1, M L Burr, E Vaughan-Williams

  • 1Prince Charles Hospital, Merthyr Tydfil.

Archives of Disease in Childhood
|April 1, 1988
PubMed
Summary
This summary is machine-generated.

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Withholding cows' milk in high-risk infants did not reduce eczema or wheezing. Soya-based formulas led to more gastrointestinal issues and oral thrush in early infancy.

Area of Science:

  • Pediatrics
  • Allergy and Immunology
  • Nutrition Science

Background:

  • Infants at high risk of allergic disease often undergo dietary interventions.
  • Cows' milk avoidance is a common strategy, but its efficacy and potential side effects require examination.

Purpose of the Study:

  • To evaluate the effect of withholding cows' milk, using a soya-based substitute, on the incidence of allergic diseases in high-risk infants.
  • To assess the occurrence of other adverse events associated with soya-based formula.

Main Methods:

  • A randomized controlled trial involving 487 high-risk infants.
  • Infants were allocated to either a control group (receiving cows' milk preparations) or an intervention group (receiving a soya-based substitute).
  • Outcomes including eczema, wheezing, napkin rash, diarrhea, and oral thrush were monitored during the first year of life.

Related Experiment Videos

Main Results:

  • No significant difference in the incidence of eczema or wheezing was observed between the cows' milk and soya-based formula groups during the first year.
  • The soya-based substitute group experienced a higher incidence of napkin rash, diarrhea, and oral thrush, particularly in the first three months.
  • Breastfeeding was associated with a reduced incidence of wheezing and diarrhea.

Conclusions:

  • Withholding cows' milk in favor of a soya-based substitute did not prevent eczema or wheezing in high-risk infants.
  • Soya-based formulas may increase the risk of certain gastrointestinal and skin issues in early infancy.
  • Breastfeeding appears to have a protective effect against wheezing and diarrhea in infants.