Related Experiment Video
Updated: Nov 15, 2025
05:52
Sentinel Lymph Node Mapping and Biopsy for Endometrial Cancer at Early Stage with Laparoscopy
Published on: August 19, 2021
12.2K
Radionuclide-guided sentinel lymph node mapping in urachal cancer
Wojciech Połom1, Wojciech Cytawa2, Anna Połom3
1Department of Urology, Medical University of Gdańsk, Poland.
Summary
This study maps urachal cancer lymph node drainage using SPECT/CT and radiotracer, revealing both unilateral and bilateral lymphatic outflow. This enables targeted sentinel lymph node biopsy for personalized cancer staging and treatment.
Area of Science:
- Oncology
- Nuclear Medicine
- Surgical Oncology
Background:
- Urachal cancer commonly metastasizes to lymph nodes (LNs).
- Current lymphadenectomy protocols for urachal cancer are lacking.
- SPECT/CT lymphangiography can assess lymphatic drainage for staging.
Purpose of the Study:
- To map LNs draining urachal cancer using a radioisotope technique.
- To propose a lymphadenectomy template for urachal cancer staging.
Main Methods:
- Prospective study of 5 urachal cancer patients.
- Preoperative injection of 99m-technetium nanocolloid.
- SPECT/CT lymphangiography, intraoperative gamma probe detection, and sentinel lymph node (SLN) biopsy.
Main Results:
- All patients showed lymphatic outflow to LNs.
- SPECT/CT identified radiotracer activity in the common iliac region.
- Lymphatic drainage was unilateral in 2 cases and bilateral in 3.
- All visualized LNs were successfully excised; SLNs were negative for metastases.
Conclusions:
- Radiotracer mapping of urachal cancer lymph node drainage is feasible.
- Lymphatic outflow can be unilateral or bilateral, necessitating individualized assessment.
- SLN basin lymphadenectomy offers a minimally invasive, targeted treatment approach.
Keywords:
dynamic sentinel lymph node biopsylymphadenectomylymphangiographysingle-photon emission computed tomography/computed tomographyurachal cancer
