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Bronchial Thermoplasty: A Novel Therapeutic Approach to Severe Asthma
Published on: November 4, 2010
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COVID-19 severity in asthma patients: a multi-center matched cohort study
Lacey B Robinson1,2, Liqin Wang2,3, Xiaoqing Fu1,4
1Division of Rheumatology, Allergy, and Immunology, Massachusetts General Hospital, Boston, MA, USA.
Summary
Asthma patients with Coronavirus disease 2019 (COVID-19) had similar hospitalization and mechanical ventilation risks but a lower mortality risk. This study clarifies the association between asthma and COVID-19 outcomes.
Area of Science:
- Pulmonology
- Infectious Diseases
- Epidemiology
Background:
- The impact of asthma on Coronavirus disease 2019 (COVID-19) outcomes remains unclear.
- Understanding this association is crucial for clinical management and public health strategies.
Purpose of the Study:
- To investigate the association between asthma and outcomes in adult patients with COVID-19.
- To clarify the risks of hospitalization, mechanical ventilation, and death in asthma patients diagnosed with COVID-19.
Main Methods:
- A matched cohort study was conducted using data from Mass General Brigham Health Care System.
- Adult patients with confirmed COVID-19 and without other major respiratory conditions were analyzed.
- Asthma patients were matched with non-asthma comparators based on age, sex, and testing date.
Main Results:
- Among 562 asthma patients, hospitalization occurred in 21%, mechanical ventilation in 3%, and death in 1%.
- Compared to matched non-asthma patients, asthma patients had adjusted Hazard Ratios of 0.99 for hospitalization, 0.69 for mechanical ventilation, and 0.30 for death.
- Asthma was associated with a statistically significant lower risk of mortality (HR 0.30, 95% CI 0.11-0.80).
Conclusions:
- Asthma was associated with comparable risks of hospitalization and mechanical ventilation in COVID-19 patients.
- Asthma was associated with a significantly lower risk of mortality among COVID-19 patients.
- Findings contribute to a clearer understanding of asthma's role in COVID-19 prognosis.
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