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Effect of Army basic training in sickle-cell trait.

I M Weisman¹, R J Zeballos, T W Martin

¹Department of Clinical Investigation, William Beaumont Army Medical Center, El Paso, Tex. 79920-5001.

Archives of Internal Medicine

|May 1, 1988

Summary

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Sickle-cell trait (SCT) does not appear to impair exercise performance or cardiovascular response to army basic training. Individuals with SCT showed similar improvements to controls, suggesting no inherent adverse effect on training adaptation.

Area of Science:

Exercise Physiology
Hematology
Sports Medicine

Background:

Sickle-cell trait (SCT) is a common inherited blood disorder.
The impact of SCT on exercise performance and training adaptation remains debated.
Objective evaluation is needed to clarify SCT's role in response to physical stress.

Purpose of the Study:

To determine if sickle-cell trait (SCT) adversely affects exercise performance in healthy individuals undergoing military training.
To objectively assess exercise capacity and cardiovascular responses in individuals with and without SCT before and after a standardized training program.

Main Methods:

A cohort of healthy black men with SCT (hemoglobin AS) and controls (hemoglobin AA) were studied.
Participants underwent a 7-week army basic training program at moderate altitude (1270 m).

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Incremental exercise tests to exhaustion on a cycle ergometer were performed pre- and post-training.

Main Results:

Before training, SCT group had slightly lower VO2 per kilogram, but peak exercise measurements were otherwise similar.
Both groups demonstrated comparable modest cardiovascular improvements after training.
No statistically significant differences were found between SCT and control groups in peak exercise variables post-training.

Conclusions:

Sickle-cell trait (SCT) does not appear to impair the response to a moderate military training regimen.
Individuals with SCT exhibit similar training adaptations in exercise performance and cardiovascular function compared to controls.
Further investigation is warranted for rare events like seizures potentially linked to SCT under extreme exertion.