Modular Approach to Substituted Pyridoazepinones.

Area of Science:

• Medicinal Chemistry
• Organic Synthesis

Background:

• Pyridoazepinones are important heterocyclic compounds.
• Their synthesis is challenging and they are underexplored in medicinal chemistry.

Purpose of the Study:

• To develop a general and flexible synthetic route to substituted pyridoazepinones.
• To enable easier access to these potentially valuable molecules.

Main Methods:

• Utilized a xanthate addition-transfer process.
• Employed readily available starting materials.

Main Results:

• Achieved generally good yields of substituted pyridoazepinones.
• Demonstrated good functional group tolerance.
• Successfully scaled the preparation to gram quantities.

Conclusions:

• The developed synthetic route is efficient and versatile.
• This method facilitates the preparation of pyridoazepinone scaffolds for further research.