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Updated: Nov 15, 2025

Synthesis of pH Dependent Pyrazole, Imidazole, and Isoindolone Dipyrrinone Fluorophores using a Claisen-Schmidt Condensation Approach
Published on: June 10, 2021
Modular Approach to Substituted Pyridoazepinones
Valentin S Dorokhov1, Samir Z Zard1
1Laboratoire de Synthèse Organique, CNRS, UMR 7652, Ecole Polytechnique, Palaiseau Cedex, 91128, France.
Abstract:
Pyridoazepinones are potentially interesting structures, yet they are still underexploited in the medicinal chemistry field and hard to obtain synthetically. We present a general and flexible synthetic route to substituted pyridoazepinones, enabled by the xanthate addition-transfer process, which furnishes the target molecules from readily available starting materials in generally good yields. The method shows good functional group tolerance and allows the preparation of pyridoazepinone scaffolds on gram scale.
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