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Related Experiment Video

Updated: Nov 15, 2025

Functional Human Liver Preservation and Recovery by Means of Subnormothermic Machine Perfusion
08:54

Functional Human Liver Preservation and Recovery by Means of Subnormothermic Machine Perfusion

Published on: April 27, 2015

17.2K

Ex-situ liver preservation with machine preservation.

Hanns Lembach Jahnsen1, Hynek Mergental1,2,3, M Thamara P R Perera1

  • 1Liver Unit, Queen Elizabeth Hospital, University Hospitals Birmingham NHS Foundation Trust (UHBFT), Birmingham.

Current Opinion in Organ Transplantation
|March 2, 2021
PubMed
Summary

Normothermic and hypothermic machine perfusion improve liver transplant outcomes. These advanced techniques enhance organ viability assessment and expand criteria for organ acceptance, benefiting more patients.

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Area of Science:

  • Organ transplantation
  • Surgical innovation
  • Graft preservation

Background:

  • Machine perfusion is an established yet rapidly evolving technique in organ transplantation.
  • Ongoing research aims to optimize perfusion strategies for different graft types and clinical scenarios.

Purpose of the Study:

  • To review recent studies on liver preservation techniques over the past three years.
  • To evaluate the benefits and limitations of various machine perfusion methods.
  • To discuss experimental applications with potential for clinical translation.

Main Methods:

  • Review of key studies in liver preservation published within the last three years.
  • Evaluation of normothermic machine perfusion (NMP) and hypothermic machine perfusion (HMP) clinical applications.
  • Analysis of novel perfusion strategies and viability assessment tools.

Main Results:

  • Normothermic machine perfusion (NMP) is now in clinical practice, with viability assessment aiding decision-making and the back-to-base approach facilitating adoption.
  • Hypothermic machine perfusion (HMP) shows promise in reducing biliary complications and improving graft function for organs from deceased donors after circulatory death (DCD) and extended criteria donors.
  • Long-term data indicates HMP improves graft survival for DCD livers compared to standard static cold storage (SCS).

Conclusions:

  • Machine perfusion techniques, including NMP and HMP, are advancing liver transplantation.
  • Further research is crucial to determine optimal indications for each perfusion strategy based on graft type and patient context.
  • Novel approaches like sequential HMP-NMP and ischemia-free preservation may further enhance outcomes for challenging organ grafts.