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Role of IL-9, IL-2RA, and IL-2RB genetic polymorphisms in coronary heart disease

Xianghong Chen1, Xingfan Wang2, Zaozhang Zhang1

  • 1Department of General Medicine, The Second Affiliated Hospital of Hainan Medical University, 570311, Haikou, China.

Herz
|March 2, 2021
PubMed

Insights

Genetic variants in interleukin-9 (IL-9), IL-2RA, and IL-2RB are associated with coronary heart disease (CHD) risk in a Han Chinese population. Specific single-nucleotide polymorphisms (SNPs) like IL-9 rs55692658 show a significant link to increased CHD susceptibility.

Area of Science:

  • Genetics
  • Cardiovascular Disease
  • Immunology

Background:

  • Coronary heart disease (CHD) is a major global health concern.
  • Inflammatory cytokines are implicated in the development of CHD.
  • Genetic predisposition may influence CHD risk.

Purpose of the Study:

  • To investigate the association between specific genetic variants of interleukin (IL)-9, IL-2RA, and IL-2RB and CHD risk.
  • To analyze the potential role of these polymorphisms in a Han Chinese population.

Main Methods:

  • A case-control study involving 499 CHD patients and 496 healthy controls.
  • Genotyping of seven single-nucleotide polymorphisms (SNPs).
  • Analysis of SNP interactions with CHD risk using multifactor dimensionality reduction (MDR).

Main Results:

  • The IL-9 rs55692658 polymorphism was associated with an increased risk of CHD (OR=1.72).
  • IL-9 rs55692658 and IL-2RB rs1573673 were significant risk factors across age groups.
  • Specific variants (IL-9 rs55692658, IL-2RA rs12722498) showed sex-specific associations in female patients.
  • IL-2RA rs12569923 was linked to diabetes risk in CHD patients.
  • MDR analysis indicated a positive interaction among the studied SNPs.

Conclusions:

  • Certain polymorphisms in IL-9, IL-2RA, and IL-2RB may be associated with CHD.
  • The findings highlight potential genetic markers for CHD susceptibility.
  • Further validation in larger cohorts is recommended.
Abstract

Keywords:
Chinese populationCoronary artery diseaseInterleukin‑2 receptor beta subunitInterleukin‑9Polymorphism, single nucleotide

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