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Urinary Biomarkers In Bladder Cancer.
Matteo Costantini1, Graziana Gallo2, Giovanna Attolini2
1Department of Pathology, Azienda Ospedaliera-Universitaria Policlinico di Modena, Modena, Italy. costantini.matteo@aou.mo.it.
Methods in Molecular Biology (Clifton, N.J.)
|March 2, 2021
Summary
Bladder cancer surveillance needs better methods than invasive cystoscopies. Research is exploring accurate, non-invasive urinary biomarkers for improved diagnosis and monitoring of bladder tumors.
Area of Science:
- Urology
- Oncology
- Biochemistry
Background:
- Bladder cancer frequently recurs, necessitating lifelong monitoring.
- Current surveillance methods like cystoscopy and cytology are invasive, costly, and have variable accuracy.
- Cytology shows low sensitivity for diagnosing low-grade bladder tumors.
Purpose of the Study:
- To review the biological basis of novel urinary biomarkers for bladder cancer.
- To discuss methodologies for detecting and analyzing these biomarkers.
- To evaluate the diagnostic performance of urinary biomarkers in bladder cancer detection and surveillance.
Main Methods:
- Literature review of studies on bladder cancer biomarkers.
- Analysis of biological pathways relevant to bladder cancer.
- Assessment of various detection and quantification techniques for urinary markers.
- Evaluation of clinical data on biomarker sensitivity and specificity.
Main Results:
- Several promising urinary biomarkers have been identified.
- Different methodologies offer varying degrees of accuracy and feasibility.
- Biomarkers show potential to improve upon current diagnostic limitations.
- Performance metrics vary based on biomarker type and tumor characteristics.
Conclusions:
- Urinary biomarkers represent a promising alternative to invasive surveillance for bladder cancer.
- Further research and clinical validation are needed to establish their role.
- Development of accurate urinary markers could significantly improve patient management and outcomes.
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