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Updated: Nov 15, 2025

Measuring the Carotid to Femoral Pulse Wave Velocity Cf-PWV to Evaluate Arterial Stiffness
05:51

Measuring the Carotid to Femoral Pulse Wave Velocity Cf-PWV to Evaluate Arterial Stiffness

Published on: May 3, 2018

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Arterial stiffness in acute COVID-19 and potential associations with clinical outcome

S Schnaubelt1, J Oppenauer1, D Tihanyi2

  • 1From the, Department of Emergency Medicine, Medical University of Vienna, Vienna, Austria.

Journal of Internal Medicine
|March 2, 2021
PubMed

Insights

Coronavirus disease 2019 (COVID-19) increases arterial stiffness, indicated by higher pulse wave velocity (PWV). This enhanced arterial stiffness may correlate with longer hospital stays and increased mortality in patients with COVID-19.

Area of Science:

  • Cardiovascular Medicine
  • Infectious Diseases
  • Vascular Biology

Background:

  • Coronavirus disease 2019 (COVID-19) is known to affect the vascular endothelium.
  • The impact of COVID-19 on arterial stiffness remains largely uncharacterized.

Purpose of the Study:

  • To investigate whether COVID-19 influences arterial stiffness.
  • To compare pulse wave velocities (PWV) in patients with and without COVID-19.

Main Methods:

  • A case-control study design was employed.
  • Brachial-ankle pulse wave velocity (baPWV) and carotid-femoral pulse wave velocity (cfPWV) were measured in acutely ill patients.
  • Patients with COVID-19 were compared to age- and sex-matched controls.

Main Results:

  • COVID-19 patients exhibited significantly higher baPWV and cfPWV compared to controls.
  • COVID-19 was independently associated with increased cfPWV and baPWV in regression analysis.
  • Elevated PWV values were observed in non-survivors, and PWV correlated with hospital stay duration in survivors.

Conclusions:

  • COVID-19 is associated with enhanced pulse wave velocity, suggesting increased arterial stiffness.
  • Elevated arterial stiffness in COVID-19 patients may be linked to prolonged hospitalization and higher mortality rates.
Abstract

Keywords:
COVID-19SARS-CoV-2arterial stiffnesscardiovascular riskpulse wave velocity

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