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Early Enteral Nutrition in Mechanically Ventilated Patients With COVID-19 Infection
Nicholas Farina1, Sarah Nordbeck1, Michelle Montgomery2
1Michigan Medicine, Department of Pharmacy, Ann Arbor, Michigan, USA.
Summary
Early enteral nutrition in mechanically ventilated COVID-19 patients did not improve outcomes. This study found no harm, suggesting further research is needed for optimal nutrition timing in severe coronavirus disease 2019.
Area of Science:
- Critical Care Medicine
- Infectious Diseases
- Nutritional Science
Background:
- Nutrition therapy is crucial for critically ill adults.
- Optimal nutrition strategies for severe COVID-19 patients are not well-established.
Purpose of the Study:
- To investigate the impact of early enteral nutrition initiation on outcomes in mechanically ventilated COVID-19 patients.
Main Methods:
- Retrospective observational study of adult COVID-19 patients on mechanical ventilation.
- Comparison of patients receiving enteral nutrition within 24 hours versus later.
- Propensity score matching to control for baseline differences.
Main Results:
- Early enteral nutrition group received higher daily calories and protein.
- No significant difference in inpatient length of stay between groups.
- Propensity score analysis confirmed higher nutrient delivery with early initiation but no outcome improvement.
Conclusions:
- Initiating enteral nutrition within 24 hours was not associated with improved outcomes in mechanically ventilated COVID-19 patients.
- No adverse effects were observed with early nutrition initiation.
- Further research is recommended to determine optimal enteral nutrition timing for COVID-19 patients requiring mechanical ventilation.
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