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Updated: Nov 15, 2025

Cutaneous Leishmaniasis in the Dorsal Skin of Hamsters: a Useful Model for the Screening of Antileishmanial Drugs

Cutaneous Leishmaniasis in the Dorsal Skin of Hamsters: a Useful Model for the Screening of Antileishmanial Drugs

Published on: April 21, 2012

Cutaneous and Mucocutaneous Leishmaniasis.

I Abadías-Granado¹, A Diago¹, P A Cerro¹

¹Servicio de Dermatología, Hospital Universitario Miguel Servet, Zaragoza, España.

Actas Dermo-Sifiliograficas

|March 2, 2021

Summary

This summary is machine-generated.

Leishmaniasis is a chronic parasitic disease caused by Leishmania protozoa, presenting in cutaneous, mucocutaneous, and visceral forms. Diagnosis involves identifying Leishmania amastigotes, with treatment challenges exacerbated by immune deficiencies.

Keywords:

Clinical manifestations Cutaneous leishmaniasis Diagnosis Diagnóstico Leishmaniasis cutánea Leishmaniasis mucocutánea Manifestaciones clínicas Mucocutaneous leishmaniasis Tratamiento Treatment

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Area of Science:

Parasitology
Infectious Diseases
Global Health

Background:

Leishmaniasis is a chronic disease caused by flagellate protozoa of the genus Leishmania.
It is a global health concern, with major endemic areas in South America, the Mediterranean, Asia, and Africa.
The disease manifests in three primary forms: cutaneous, mucocutaneous, and visceral (kala-azar), with visceral leishmaniasis being the most severe.

Purpose of the Study:

To provide an overview of leishmaniasis, including its causative agents, global distribution, clinical manifestations, diagnostic methods, and treatment considerations.
To highlight the evolving presentation and management of leishmaniasis, particularly in the context of compromised immune systems.

Main Methods:

Diagnosis relies on identifying Leishmania amastigotes in clinical specimens.
Methods include direct microscopic examination and molecular analysis.
Evidence for treatment options, especially for cutaneous leishmaniasis, is noted as weak.

Main Results:

Leishmaniasis is a significant global disease with diverse clinical presentations.
Diagnostic confirmation involves direct visualization or molecular detection of the parasite.
Treatment efficacy varies, and management is increasingly complex due to factors like HIV and TNF inhibitor use.

Conclusions:

Leishmaniasis remains a critical infectious disease requiring accurate diagnosis and effective management strategies.
The disease's epidemiology and clinical course are influenced by host immune status, necessitating adaptive treatment approaches.
Further research is needed to strengthen the evidence base for cutaneous leishmaniasis treatments.