Related Experiment Video
Updated: Nov 15, 2025
11:44
Surface Enhanced Raman Spectroscopy Detection of Biomolecules Using EBL Fabricated Nanostructured Substrates
Published on: March 20, 2015
20.9K
Composite Structure Based on Gold-Nanoparticle Layer and HMM for Surface-Enhanced Raman Spectroscopy Analysis
Zirui Wang1, Yanyan Huo1,2, Tingyin Ning1,2
1Collaborative Innovation Center of Light Manipulations and Applications in Universities of Shandong School of Physics and Electronics, Shandong Normal University, Jinan 250014, China.
Nanomaterials (Basel, Switzerland)
|March 3, 2021
Summary
This study presents a novel composite surface-enhanced Raman scattering (SERS) substrate using hyperbolic metamaterials and gold nanoparticles. The developed SERS substrate shows enhanced detection capabilities for molecules like R6G and MG.
Area of Science:
- Plasmonics and Nanomaterials
- Spectroscopy and Sensing
Background:
- Hyperbolic metamaterials (HMMs) support surface and bulk plasmon polaritons, showing potential for surface-enhanced Raman scattering (SERS) substrates.
- Existing SERS substrates face challenges in sensitivity and detection limits for various analytes.
Purpose of the Study:
- To fabricate and characterize a composite SERS substrate using a multilayer HMM and gold nanoparticle (Au-NP) layer.
- To investigate the electromagnetic field enhancement mechanism and the effect of HMM periods on SERS performance.
- To evaluate the detection limits, reproducibility, and stability of the developed SERS substrate.
Main Methods:
- Fabrication of a multilayer HMM combined with an Au-NP layer.
- Characterization of the composite structure and electromagnetic field enhancement via COMSOL simulations.
- Experimental assessment of SERS performance using rhodamine 6G (R6G) and malachite green (MG) as probe molecules.
Main Results:
- A strong electromagnetic field was generated at Au-NP nanogaps due to coupled localized surface plasmon resonance (LSPR) and bulk plasmon polaritons (BPPs).
- Experimental and simulation results showed enhanced SERS performance, with performance decreasing as HMM periods increased.
- Achieved low limits of detection: 10-10 M for R6G and 10-8 M for MG, alongside excellent reproducibility and stability.
Conclusions:
- The composite HMM-Au-NP structure is a highly effective SERS substrate with significant potential for sensitive molecule detection.
- The substrate demonstrates promising applications in fields such as biosensing and food safety inspection due to its high performance and stability.
