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Related Concept Videos

Two-dimensional Gel Electrophoresis01:22

Two-dimensional Gel Electrophoresis

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Two-dimensional gel electrophoresis is a high-resolution protein separation method first introduced by O' Farrell and Klose in 1975. This method involves protein separation by two dimensions, mass and charge, making it more accurate than one-dimensional gel electrophoresis.
The first dimension separation uses the isoelectric focusing or IEF technique performed on immobilized pH gradient (IPG) strips that separate proteins according to their isoelectric points.
Biological samples, such...
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The glycocalyx is a carbohydrate-rich, fuzzy-appearing layer on the outer surface of the cell membrane. It is highly hydrophilic, because of this it attracts large amounts of water to the cell's surface. This aids the cell's interaction with the watery environment and also helps it to obtain substances dissolved in the water. It is also important for cell identification, self/non-self determination, and embryonic development and is used in cell-to-cell attachments to form tissues.
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Agarose gel electrophoresis is a laboratory technique commonly used to separate DNA fragments by size. However, it can also be used to isolate and purify DNA fragments using a gel extraction protocol.
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Updated: Nov 15, 2025

Thermal Scanning Conductometry TSC as a General Method for Studying and Controlling the Phase Behavior of Conductive Physical Gels
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Recently Developed Carbohydrate Based Gelators and Their Applications.

Joedian Morris1, Jonathan Bietsch1, Kristen Bashaw1

  • 1Department of Chemistry and Biochemistry, Old Dominion University, Norfolk, VA 23529, USA.

Gels (Basel, Switzerland)
|March 3, 2021
PubMed
Summary

Carbohydrate-based low molecular weight gelators (LMWGs) offer biocompatible and renewable self-assembling systems. This review highlights their design, properties, and applications in areas like drug delivery and environmental remediation.

Keywords:
carbohydratesdrug deliveryhydrogelatorshydrogelsmetallogelsmonosaccharidesorganogelatorsstimuli-responsivesupramolecular gels

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Area of Science:

  • Supramolecular Chemistry
  • Materials Science
  • Carbohydrate Chemistry

Background:

  • Carbohydrate-based low molecular weight gelators (LMWGs) are significant due to their biocompatibility and renewable origins.
  • Naturally occurring monosaccharides provide diverse structures for constructing effective gelators.
  • Self-assembly strategies are crucial for developing LMWGs for various applications.

Purpose of the Study:

  • To review literature on monosaccharide-based gelators from 2017-2020.
  • To elucidate structure-gelation property relationships and stimuli-responsive behaviors.
  • To highlight applications of sugar-based gelators in diverse fields.

Main Methods:

  • Literature review of monosaccharide and disaccharide-based gelators.
  • Analysis of structure-based design principles.
  • Examination of structure-property correlations for gelator applications.

Main Results:

  • Multiple classes of molecular gelators have been developed through rational design and discovery.
  • Structure-gelation relationships and stimuli-responsive properties are key design considerations.
  • Sugar-based gelators show promise in environmental remediation, sensing, catalysis, drug delivery, and 3D printing.

Conclusions:

  • Understanding design principles and structural features is crucial for optimizing sugar-based gelators.
  • These gelators offer versatile platforms for advanced material applications.
  • Guidelines are provided for researchers in chemistry, biochemistry, and materials science.