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Incomplete Dominance

Incomplete Dominance

Gregor Mendel's work (1822 - 1884) was primarily focused on pea plants. Through his initial experiments, he determined that every gene in a diploid cell has two variants called alleles inherited from each parent. He suggested that amongst these two alleles, one allele is dominant in character and the other recessive. The combination of alleles determines the phenotype of a gene in an organism.

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Related Experiment Video

Updated: Nov 15, 2025

Evaluation of Planar-Cell-Polarity Phenotypes in Ciliopathy Mouse Mutant Cochlea

Evaluation of Planar-Cell-Polarity Phenotypes in Ciliopathy Mouse Mutant Cochlea

Published on: February 21, 2016

Experimental Models for the Study of Hereditary Cornification Defects.

Dragan Copic^1,2, Maria Laggner^1,2, Polina Kalinina³

¹Laboratory for Cardiac and Thoracic Diagnosis, Regeneration and Applied Immunology, Department of Surgery, Research Laboratories, Medical University of Vienna, 1090 Vienna, Austria.

|March 3, 2021

Summary

Ichthyoses are genetic skin barrier disorders caused by mutations in over 50 genes. This review explores current models for studying these complex hereditary cornification defects.

Keywords:

cornification defect gene knockdown ichthyosis organotypic skin model

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Last Updated: Nov 15, 2025

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Area of Science:

Dermatology
Genetics
Molecular Biology

Background:

Ichthyoses represent a diverse group of inherited keratinization disorders.
Over 50 causative genes, primarily encoding structural epidermal proteins, have been identified.
Research is hindered by genetic heterogeneity and challenges in developing valid experimental models.

Purpose of the Study:

To review existing experimental models for studying hereditary cornification defects.
To focus on models relevant to ichthyoses and palmoplantar keratodermas.
To address the challenges in translating research findings to clinical practice.

Main Methods:

Literature review of existing research models.
Analysis of genetic databases and mutation identification.
Discussion of experimental approaches for studying keratinization.

Main Results:

Identification of over 50 genes linked to ichthyoses.
Highlighting the heterogeneity of genetic causes.
Acknowledging the difficulties in establishing suitable research models.

Conclusions:

Effective models are crucial for advancing the understanding of ichthyoses.
Further development of experimental models is needed.
Bridging the gap between research and clinical application remains a key challenge.