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Updated: Nov 15, 2025

Identification of Post-translational Modifications of Plant Protein Complexes
Published on: February 22, 2014
Protein S-palmitoylation in immunity
Tandrila Das1, Jacob S Yount2, Howard C Hang1,3
1Laboratory of Chemical Biology and Microbial Pathogenesis, The Rockefeller University, New York, NY 10065, USA.
Abstract:
S-palmitoylation is a reversible posttranslational lipid modification of proteins. It controls protein activity, stability, trafficking and protein-protein interactions. Recent global profiling of immune cells and targeted analysis have identified many S-palmitoylated immunity-associated proteins. Here, we review S-palmitoylated immune receptors and effectors, and their dynamic regulation at cellular membranes to generate specific and balanced immune responses. We also highlight how this understanding can drive therapeutic advances to pharmacologically modulate immune responses.
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