Ophthalmic anterior segment metastasis masquerading as uveitis

Area of Science:

• Ophthalmology
• Oncology
• Pulmonology

Background:

• Ocular malignancies are rare, often presenting as metastases from primary tumors like breast, lung, or gastrointestinal cancers.
• Late diagnosis of ocular metastases frequently leads to poor patient outcomes.
• Treatment for ocular metastases depends on the primary tumor and patient status, typically involving systemic therapy or radiation.

Purpose of the Study:

• To present a unique case of ocular malignancy with neuroendocrine small cell features originating from the lung.
• To emphasize the importance of ophthalmic examination in diagnosing unexpected metastatic disease.
• To illustrate the efficacy of systemic chemotherapy in managing ocular metastases from small cell lung carcinoma.

Main Methods:

• A meticulous ophthalmic examination was performed.
• Diagnostic procedures confirmed small cell lung carcinoma with anterior segment metastasis.
• The patient received six cycles of systemic chemotherapy.

Main Results:

• The diagnosis of small cell lung carcinoma with anterior segment metastasis was established.
• Systemic chemotherapy resulted in a favorable response.
• The patient experienced improvement in vision and regression of the ocular lesion.

Conclusions:

• Ocular metastasis from small cell lung carcinoma, though rare, can occur in patients without a prior oncological history.
• Prompt ophthalmic evaluation is crucial for diagnosing ocular malignancies.
• Systemic chemotherapy can be an effective treatment for ocular metastases, leading to improved visual function and tumor regression.