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At the Heart of Immune Checkpoint Inhibitor-Induced Immune Toxicity

Arabella Young1,2, Jeffrey A Bluestone3,4

  • 1Sean N. Parker Autoimmune Research Laboratory and Diabetes Center, University of California, San Francisco, San Francisco, California.

Cancer Discovery
|March 3, 2021
PubMed

Wei and colleagues showcase a genetic mouse model of immune-mediated myocarditis that shares homology with immune checkpoint inhibitor (CPI)-induced myocarditis in patients with cancer. They demonstrate that abatacept (CTLA4-Ig) limits cardiac toxicity in the mouse model and, thus, may ameliorate the CPI-induced myocarditis in patients with cancer while potentially maintaining antitumor activity.See related article by Wei et al., p. 614.

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